Relationship Between Platelets/Lymphocytes And Monocyte/High Density Lipoprotein Ratio And Coronary Heart Disease

Objectives To study the relationship between platelet/lymphocyte and monocyte/high density lipoprotein ratio and CHD in patients with CHD,so as to provide certain reference value for predicting the severity and risk stratification of coronary artery disease in patients with CHD.Methods From October 2018 to December 2020,210 patients with coronary heart disease(CHD)diagnosed by coronary angiography were collected in the Department of Cardiovascular Medicine,North China University of Science and Technology Affiliated Hospital,and 110 healthy people with normal coronary angiography were selected as controls.According to the clinical types of CHD,it can be divided into two groups,including 92 cases of stable angina(SA)group and 118 cases of acute coronary syndromes(ACS)group.According to SYNTAX Ⅱ score,patients with CHD were further divided into low risk group(< 21)56 cases,medium risk group(22 ≤ SYNTAXⅡ≤ 28)102 cases and high risk group(> 28)52 cases.After hospitalization,all patients collected some basic data of the patients,mainly including age,history of hypertension,history of diabetes mellitus(DM),history of smoking,drinking,history of peripheral vascular diseases,history of chronic obstructive pulmonary disease,family history,etc.,and measured height and weight,calculated body mass index(BMI),and checked cardiac color Doppler ultrasound after admission to determine ejection fraction.Venous blood was drawn and laboratory parameters were strictly recorded as required.After hospitalization,all patients selected emergency or elective coronary angiography according to the actual condition,confirmed the specific angiography data,scored SYNTAXⅠ and SYNTAXⅡ and obtained the values.At the same time,patients with CHD were divided into low-risk group,medium-risk group and high-risk group according to SYNTAXⅡ score,and the utilization rate and composition ratio of counting data were expressed accordingly.Chi-square test was used in the treatment of inter-group comparison.The measurement data had corresponding normal distribution,the data conforming to the homogeneity of variance were expressed by (?)±s,the research was carried out by single factor variance scheme,and the comparison between groups was processed by LSD-t test method;The risk factors of CHD was determined by multivariate logistic regression analysis;Spearman correlation analysis was used to evaluate the correlation between PLR,MHR and SYNTAX Ⅱ Ⅱ score and other biomarkers related to CHD.Results 1.The MHR and PLR of CHD group were higher than those of the control group,and the difference was statistically significant(P<0.05).2.MHR and PLR in ACS group were higher than those in SA group,and the difference was statistically significant(P<0.05).3.According to SYNTAXⅡ,the PLR and MHR of the middle and high risk groups were higher than those of the low risk group,and the difference was statistically significant(P<0.05);PLR and MHR of CHD patients were positively correlated with SYNTAXⅡ scores(r values were 0.425,0.648,P<0.01,respectively);Logistic regression analysis showed that MHR,PLR,hypertension,diabetes mellitus and MPV were independent risk factors of CHD with CHD as dependent variable and various clinical data as independent variables.4.Compared with the control group,CHD group had no statistical significance in gender(P>0.05),but had statistical significance in smoking history,diabetes history and hypertension history(P<0.05);There was no significant difference in age,hemoglobin,platelet,uric acid,serum creatinine,random blood glucose,BMI,TC and TG between CHD group and control group(P>0.05);LDL and MPV in CHD group were higher than those in control group(P<0.05);HDL in CHD group was lower than that in control group,and the difference was statistically significant.5.According to SYNTAXⅡ,they were divided into low-risk group and medium-risk group.Compared with the high-risk group,there was no statistical significance in age,hemoglobin,platelets,serum creatinine,random blood glucose,TC,TG,UA,BMI,and LDL(P>0.05);NLR and MPV in middle and high risk groups were higher than those in low risk group(P<0.05);HDL in high risk group < middle risk group < low risk group(P<0.05);There were significant differences in HDL and MPV among the three groups(P<0.05).6.The ROC curve was drawn to evaluate the predictive value of PLR,MHR alone and the combination of PLR and MHR on SYNTAXⅡ score.The results showed that the area under the curve(AUC)when PLR alone was used to predict CHD was 0.837(95% CI: 0.805-0.869,P<0.01).When the PLR cut value was 118.4,the diagnostic value was the highest,the sensitivity was 81.6%,and the specificity was 78.6%.When using MHR alone to predict CHD,the area under the curve(AUC)was 0.768(95% CI: 0.731-0.804,P<0.01).When the MHR cut value was 0.33,the diagnostic value was the highest,the sensitivity was 82.4%,and the specificity was 66.4%.When PLR and MHR were combined,the AUC increased to 0.875(95% CI: 0.847-0.902,P<0.01).Conclusions 1.PLR and MHR are positively correlated with SYNTAXⅡ score of CHD,and they are independent risk factors for patients with CHD.2.When MHR > 0.33 and PLR > 118.4,the SYNTAXⅡ score of CHD is higher.Figure 3;Table 9;Reference 175.