Study On The Correlation Between The Size Of Parathyroid Adenoma And The Function Of Parathyroid And Thyroid

Objectives To explore the relationship between the size of parathyroid adenoma and parathyroid function and thyroid function,and to explore the relationship between parathyroid adenoma and thyroid disease.Methods We collected the clinical data of 100 patients with parathyroid adenoma who were diagnosed and treated from January 2000 to February 2021 in our hospital.The correlation between the size of parathyroid adenoma and preoperative indexes and preoperative indexes was obtained by person correlation analysis.The influencing factors of the size of parathyroid adenoma were obtained by logistic regression analysis.The value of preoperative indexes in predicting the size of parathyroid adenoma was obtained by ROC curve analysis,and to explore the influence of the size of parathyroid adenoma on parathyroid and thyroid function and further analyze the influence of parathyroid function on thyroid function.T-test was used to analyze the influence of parathyroid adenoma combined with thyroid disease on preoperative indexes of patients with parathyroid adenoma,and to explore the relationship between parathyroid adenoma and thyroid disease.Results 1 The size of parathyroid adenoma was positively correlated with PTH level,serum calcium,corrected serum calcium,creatinine level and course of disease(P<0.01),and negatively correlated with free thyroxine level(P<0.01).2 The PTH level was positively correlated with serum calcium,corrected serum calcium,ALP,creatinine and course of disease(P<0.01),and negatively correlated with serum phosphorus,TT4 and FT4(P<0.01).3 The level of TT4 was negatively correlated with serum calcium,corrected serum calcium,ALP,creatinine and the course of disease(P<0.01),and positively correlated with serum phosphorus(P<0.01).4 The level of FT4 before operation was negatively correlated with serum calcium,corrected serum calcium and course of disease(P<0.01).5 Logistic regression analysis showed that PTH and course of disease were the influencing factors of patients with larger adenoma(P<0.05).6 The area under curve(AUC)of newly generated y,PTH and course variables were0.887,0.882 and 0.845,respectively,and there was no significant difference among them(z=0.011 and 0.130,respectively,P>0.05).The sensitivity of preoperative PTH and course of disease in predicting macroadenoma was 74.6% and 62.7%,respectively.The sensitivity of combined detection of PTH and course of disease in predicting macroadenoma was 79.7%.7In this group,parathyroid adenoma patients with thyroid diseases accounted for 55%,mainly including 20 patients with thyroid nodules,27 patients with nodular goiter,7 patients with Hashimoto’s thyroiditis,1 patient with thyroid papillary carcinoma.The course of disease in patients with thyroid diseases was shorter than that in patients without thyroid diseases(P<0.05).Conclusions 1 In this study,we found that the size of PTA is positively correlated with its own function.The combined consideration of PTH level and course of disease can further improve the sensitivity of predicting larger adenoma.2 PTA patients are easy to be accompanied with thyroid diseases,and hyperparathyroidism may play an inhibitory role in thyroid function.Figure8;Table9;Reference196...