Clinical Observation Of Qinghua Tongluo Decoction Combined With Mesalazine Enteric-coated Tablets In The Treatment Of Ulcerative Colitis Of Damp-heat Type Of Large Intestine

Objectives This study aims to evaluate the clinical efficacy and safety of Qinghua Tongluo Decoction combined with Mesalazine enteric-coated tablet in the treatment of ulcerative colitis damp-heat type of large intestine.Methods Sixty-eight patients were selected as the research subjects.These patients were diagnosed with ulcerative colitis of damp-heat type of large intestine by the Anorectal Department and Gastroenterology Department of Tangshan Hospital of Traditional Chinese Medicine.According to the order of treatment,they were divided into two groups by random number table method,with 34 cases in each group.The control group were orally administered Mesalazine enteric-coated tablet 1.0g,3 times a day.On the basis of control group,the experimental group were orally administered Qinghua Tongluo Decoction 200 ml,twice a day.Both groups were treated for 4 weeks.The TCM syndrome score,colonoscopy mucosal score,C-reactive protein(CRP),erythrocyte sedimentation rate(ESR),alanine aminotransferase(ALT),aspartate aminotransferase(AST),serum creatinine(Cr),Blood urea nitrogen(Bun)and other indicators before and after the experiment were analyzed to evaluate the efficacy and safety of Qinghua Tongluo decoction combined with Mesalazine enteric-coated tablets in the treatment of ulcerative colitis dampness-heat type of large intestine.SPSS 22.0 was used for Statistical analysis,and the difference was statistically significant when P < 0.05.If intestinal obstruction,intestinal perforation or other serious adverse reactions occur during treatment,the causes should be analyzed and timely symptomatic treatment should be made.Those who could not continue to complete the trial were excluded,and the adverse reactions and treatment methods were recorded completely.After comprehensive analysis of the data obtained in clinical observation,the conclusion was drawn.Results 1 There was no statistically significant difference between the two groups in terms of baseline data,gender,severity of disease,age,lesion range and course of disease(P > 0.05),indicating that the two groups were comparable.2 After 4 weeks of treatment,the total effective rates of the experimental group and the control group in the treatment of TCM symptoms were 93.75 % and 73.53 %,respectively.The effective rate of the experimental group was higher than that of the control group,and the difference was statistically significant(P < 0.05).3 TCM symptom scores : Compared with before treatment,the TCM symptom scores of the two groups decreased after treatment,and the difference was statistically significant(P < 0.05);Compared with the control group,there was a prominent decrease in the main TCM symptoms of pus and bloody stool,abdominal pain,acute symptoms and secondary TCM symptoms of dampness and heat of anus,short red urine,dry mouth and bitter mouth,abdominal distension in the test group(P < 0.05).There was no statistical significance in the numbers of diarrhea between the test group and the control group(P > 0.05).4 Comparison of mucosal score: there was a significant difference between the two groups before and after treatment(P < 0.05),indicating that the two treatment schemes were effective in improving intestinal mucosa,and there was significant difference between the two groups(P < 0.05).5 Comparison of endoscopic response: 29 of 32 patients in the experimental group received endoscopic response after treatment,and 24 of 34 patients in the control group received endoscopic response.The endoscopic response of the two groups was compared,P < 0.05,and the difference was statistically significant.6 Comparison of endoscopic mucosal healing: After treatment,there were 20 cases of endoscopic mucosal healing in 32 patients in the experimental group and 11 cases of endoscopic mucosal healing in 34 patients in the control group.The endoscopic response of the two groups was compared,P < 0.05,and the difference was statistically significant.7 Long-term efficacy: After one month of treatment,3 of the 30 effective patients in the experimental group had recurrence,with a recurrence rate of 10%,and 8 of the 25 effective patients in the control group had recurrence,with a recurrence rate of 32%,with statistical significance(P < 0.05).8 Comparison of serum inflammatory indicators: Compared with before treatment,CRP and ESR of 2 groups were decreased after treatment,with statistical significance(P < 0.05).Compared with the control group,the treatment group showed a significant decrease(P < 0.05).9 Safety indexes: ALT,AST,Cr,Renal function and blood routine did not change significantly between the two groups(P > 0.05).There were no serious adverse reactions in two groups during treatment.Conclusions 1 Qinghua Tongluo Decoction combined with Mesalazine enteric-coated tablets can improve the clinical symptoms of patients with large intestine damp-heat type UC.The therapeutic effect on the three main symptoms of bloody purulent stool,abdominal pain,tenesmus and the four minor symptoms of burning anus,short red urine,dry mouth and bitter mouth,abdominal distension was better than the single application of Mesalazine enteric-coated tablet.2 Qinghua Tongluo Decoction combined with Mesalazine enteric-coated tablet has better efficacy than Mesalazine eteric-coated Tablet alone in promoting mucosal repair under colonoscopy and reducing recurrence rate.3Qinghua Tongluo Decoction combined with Mesalazine enteric-coated tablet is safe and effective in the treatment of ulcerative colitis,without obvious adverse reactions and side effects.Figure0;Table24;Reference 162...