Facial Recognition Event-Related Potentials In Patients With Post-Stroke Depression

Objectives In order to provide an objective basis for the early evaluation of cognitive dysfunction in convalescent patients with post-ischemic stroke depression,a study on face recognition related potentials was conducted.Methods Continuous selection of 2019.09-2020.09 kailuan general hospital nerve in ternal medicine outpatient clinic visits or multiple in hospital patients,142 cases of l acunar cerebral infarction convalescence and in patients admitted to hospital 24 hou rs recordsage,race,marriage status,educational level,evaluation always hypertension High homocysteine levels,diabetes History of hyperlipidemia,and family history of mental illness history of smoking and alcohol consumption,and improve mri brain s cans,record the distribution of the cerebral infarction lesions.Within one week,combi ned with patients’ medical history and clinical manifestations,Self-rating depression sc ale(SDS)and Mini-Mental State Examination(MMSE)was used to assess patients’ mo od and cognitive function.According to the results of MMSE and SDS,the participan ts were divided into three groups:simple stroke group(control group)and post-stroke depression group(PSD group).Poststroke depression with cognitive impairment group(PSD and PSCI group).The three groups of patients were tested for potential related to facial recognition events(N170 VPP N300 P100),and the specific values of pote ntial amplitude peak latency of each patient were recorded to observe the changes of potential amplitude latency of the three groups of general clinical data.SPSS22.0 was used to conduct χ2 test and one-way analysis of variance for the obtained data.Results 1.The proportion of students with junior high school education or above in the PSD combined with PSCI group was lower than that in the PSD group and the control group,and the SDS score in the PSD group and the PSD group comb ined with cognitive impairment group was higher than that in the control group,th e difference was statistically significant(P<0.05).The mean MMSE scores of control group and PSD group were higher than those of PSD combined with PSCI group,and the difference was statistically significant(P<0.05).Lacunar infarct lesions are wi dely distributed,mainly located in the center of semiovale,basal ganglia and lateral ventricle.2.The smoking rate of PSD combined with PSCI group was significantl y higher than that of control group and PSD group(P<0.05).The incidence of alcoho l consumption in the PSD group and PSD combined with PSCI group was higher t han that in the control group,and the difference was statistically significant(P<0.05).3.P100 component:When stimulated by an inverted face,the analysis of variance of P100 wave amplitude in the three groups showed that there was significant differe nce only in PO3 and PO1 electrodes(P<0.05),The PSD combined with PSCI group was significantly lower than the control group(P<0.05),Under the stimulation of upri ght face,inverted house and upright house,PO1,PO2,PO4 and PO3 electrode P100 a mplitudes were significantly different in three groups(P<0.05);The P100 amplitude(PO1,PO2,PO4,PO3)of PSD combined with PSCI group was lower than that of control group(P<0.05),and the P100 amplitude(PO3,PO1)of PSD group was lo wer than that of control group(P<0.05).The P100 amplitude(PO2 and PO4)of P SD combined with PSCI group was lower than that of PSD group(P<0.05)when stimulated by upright face and inverted house.4 N170 component:There were signif icant differences in N170 peak latency(P7,PO7,PO8,P8)among the three groups(all P<0.05).The peak latency of PSD combined with PSCI group was longer tha n that of PSD group and control group,respectively(all P<0.05).There were signif icant differences in amplitude(P7,PO7,PO8,P8)among the three groups(all P<0.05).The amplitude of PSD combined with PSCI group was significantly lower than that of control group and PSD group(all P<0.05).The amplitude of N170(P7,P O7)in PSD group was lower than that in control group(P<0.05).The difference o f amplitude(P7 and PO7)among the three groups was statistically significant(all P<0.05).The amplitude of N170 in the PSD combined with PSCI group was lower than that in the PSD group than that in the control group(all P<0.05).There was significant difference in amplitude(P8)among the three groups(P<0.05).The amp litude of PSD combined with PSCI group was significantly lower than that of the control group(P<0.05).5.VPP component:The peak latency(FZ,CZ)of PSD com bined with PSCI group was longer than that of control group and PSD group(all P<0.05).There were significant differences in VPP amplitude(FZ,CZ)among the three groups(all P<0.05).The amplitude of PSD combined with PSCI group was l ower than that of the control group(all P<0.05).The difference of VPP amplitude(FZ)among the three groups was statistically significant(P<0.05).The amplitude of PSD combined with PSCI group and PSD group was lower than that of the contr ol group(all P<0.05).6.N300 component:The peak latency(CZ)of the three grou ps was statistically significant(all P<0.05).The latency of the PSD combined with PSCI group was longer than that of the PSD group and the control group respectiv ely(all P<0.05).Under the stimulation of the inverted house,there was statistically significant difference(CZ)between the three groups(all P<0.05).The incubation p eriod of PSD combined with PSCI group was longer than that of control group(P<0.05),and the incubation period of PSD group was longer than that of control gr oup(P<0.05).Conclusions 1 Education level,smoking and alcohol consumption may influence the cognitive function after stroke.The infarct lesions in the center of semiovale,basal ganglia and lateral ventricle may be the neuropathological basis of depression and impaired cognitive function after lacunar infarction in the convalesce stage.2 The event-related potentials(N170)of PSD patients combined with PSCI showed significant changes during the stimulation of inverted faces.3 In PSD patients,the event-related potentials of face recognition can change to different degrees,which can be used to evaluate the early and latent cognitive function of PSD patients,but it needs to be combined with P100,N170,VPP and N300,and under different kinds of stimuli.Figure6;Table26;Reference 90...