Effects Of Recombinant Human Growth Hormone On Eye Development In Children With Short Stature

Objectives Analyze the difference of eyeball development between children with growth hormone deficiency and normal children,and observe the development of eyeball after the application of recombinant human growth hormone.Methods From October 2019 to October 2020,50 patients(100 eyes)with dwarfism and 50 normal children(100 eyes)with physical examination in Tangshan maternal and child health hospital from 5 to 8 years old were selected as the research objects.Before the treatment,the patients with dwarfism and normal children were examined,and the differences of eyeball parameters between the patients with dwarfism and normal children were analyzed.After treatment,according to whether to use recombinant human glucocorticoid,patients with short stature were divided into hormone treatment group and conservative treatment group,and the normal children were included in the control group. The eyeball parameters of the three groups were recorded before treatment,6 months and12 months after treatment,and the differences among the three groups were analyzed.All the data were analyzed by SPSS software,and the effects of recombinant human growth hormone on the development of eyeball in patients with short stature were discussed.Results 1 Growth hormone deficiency led to slow eyeball development in patients with short stature.Compared with normal children,the axial length and equivalent spherical lens value of patients with short stature were shorter,however,the difference in the front depth,lens thickness,corneal refractive power and distance vision between the two was not obvious.2 The axial growth and equivalent spherical lens decrease of patients with recombinant human glucocorticoid were faster than those with conservative treatment.After recombinant human glucocorticoid treatment,the development of eyeball in the first 6 months was faster than that in the second 6 months.3 The eyeball development of5-6 years old patients treated with recombinant human glucocorticoid basically reached the normal level of children of the same age.The difference of eyeball axis and equivalent spherical lens between 6-7 years old and 7-8 years old patients and normal children of the same age decreased.Conclusions 1 The development of eyeball in patients with short stature is lower than that in normal children due to growth hormone deficiency.2 Recombinant human growth hormone can promote the development of eyeball,increase the axial length and decrease the equivalent spherical lens in patients with short stature.3 After the application of recombinant human growth hormone,the patients can reach the level of normal children’s eye development or reduce the difference between them,shorten the time of emmetropia,and even enter the stage of myopia at an early stage like normal children.Figure 10;Table 26;Reference 112...