Application Of Photothermal Nanocarriers In Tumor Treatment

Photothermal therapy is a new type of minimally invasive treatment for cancer,which can effectively avoid the toxic and side effects of traditional cancer treatments.However,photothermal therapy currently has certain limitations,such as stimulating the expression of heat shock proteins(HSPs)to inhibit tumor cell apoptosis,and the limited penetration depth is difficult to eradicate tumors.In response to these problems,this paper uses carbon-silica nanoparticles(CSN)with a uniform,regular and mesoporous structure as a carrier to load the pro-apoptotic peptide ZXR-1 and functional trimanganese tetroxide(Mn3O4)nanoparticles to carry out anti-tumor research.The CSN(CSN-ZXR-1)loaded with a polypeptide that promotes apoptosis can release ZXR-1 in response to near-infrared light after reaching the tumor site,realizing photo-thermal synergistic cancer therapy.In addition,CSN-ZXR-1 is further coated with a cell membrane derived from macrophages(CSN-ZXR-1@M)to enhance the material’s targeting of tumor cells.The multifunctional nanoparticle has shown good effects in tumor suppression experiments in vivo and in vitro,achieving high tumor suppression rate.In order to solve the problem of tumor recurrence,the light heat carrier CSN is used to load ultra-small nanoparticles Mn3O4(CSN-Mn3O4)with superoxide dismutase(SOD)and catalase(CAT)-like activities.The nanocomposite particles can It eliminates excessive superoxide anions in the tumor microenvironment and catalyzes hydrogen peroxide to produce O2.Under near-infrared light irradiation,it is beneficial to inhibit the renewal ability of tumor stem cells and improve the efficiency of photothermal treatment.It has a good application prospect in vivo.