| BackgroundDilated cardiomyopathy(DCM)is one kind of cardiovascular disease,which severely threatens the health of human.Currently,neuroendocrine factors and inflammatory factors are considered to play an important role in the pathogenesis of DCM because they are widely involved in the myocardial fibrosis and ventricular remodeling process of DCM.Therefore,it is significant to further investigate the function of neuroendocrine factors and inflammatory factors in the pathogenesis of DCM.Chemerin is one kind of inflammatory factor,which is secreted by adipocyte.Mid-regional fragment of pro-adrenomedullin(MR-ProADM)belonging to calcitonin related peptide family is one kind of neurohormonal factor,which is secreted increasingly in stress.Growth differentiation factor 15(GDF-15)belonging to trasnforming growth factor β superfamily is one kind of inflammatory factor,which is secreted increasingly during inflammatory reaction and participates in cell differentiation-Current studies have found that Chemerin,MR-ProADM and GDF-15 are increased in coronary heart disease,chronic heart failure and other cardiovascular diseases,suggesting that they are involved in the occurrence and progression of a variety of cardiovascular diseases.However,it is not clear that the changes of the above-mentioned three kinds of factors in DCM and whether they also participate in the pathogenesis of DCM.Therefore,it is necessary to explore the levels and significance of Chemerin,MR-ProADM and GDF-15 in DCM patients.ObjectivesTo explore the levels and significance of Chemerin,MR-ProADM and GDF-15 in DCM patients through testing the serum concentrations of Chemerin,MR-ProADM and GDF-15 in DCM patientsMethodsFrom August 2019 to April 2021,130 patients with dilated cardiomyopathy in the Department of Cardiology of the First Affiliated Hospital of Zhengzhou University were slected as experimental group,while 120 subjects who received health examination matched in age and sex in the same period were selected as the control group.The basic medical history data of the two groups were collected,while the blood routine,renal function,liver function,blood glucose and blood lipid were tested in the laboratory.Serum Chemerin,MR-ProADM and GDF-15 in the two groups were measured by ELISA method.Left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD)and left atrial anteroposterior diameter were measured by echocardiography.SPSS 19.0 software was used for statistical analysis.The correlation between serum Chemerin,MR-ProADM,GDF-15 and echocardiography indexes were analyzed by Pearson correlation analysis,P<0.05 was statistically significantResults1.There were no significant differences in age,sex,smoking history,drinking history,hypertension history,diabetes history,hemoglobin,total cholesterol and triglyceride between the two groups(all P>0.05).The concentraions of serum creatinine,uric acid,NT-proBNP and LVEDD,left atrial anteroposterior diameter in DCM group were higher than those in control group(all P<0.001).LVEF of DCM group lower than that in control group(P<0.001).2.The levels of Chemerin,MR-ProADM and GDF-15 in DCM group were(98.3±19.9)ng/ml,(535.5±120.4)pg/ml and(1280.2±273.3)pg/ml respectively,which were significantly higher than those in control group(50.3±11.4)ng/ml,(270.2±77.9)pg/ml,and(701.8 ±183.9)pg/ml respectively(all P<0.001).3.The serum concentration of Chemerin in DCM group was moderately positively correlated with the concentration of MR-ProADM and GDF-15,while the concentration of MR-ProADM was moderately positively correlated with that of GDF-15(all P<0.001).4.Serum Chemerin concentration in DCM group was positively correlated with LVEDD and left atrial anteroposterior diameter,but negatively correlated with LVEF(all P<0.001).5.Serum MR-ProADM concentration in DCM group was positively correlated with LVEDD and left atrial anteroposterior diameter,but negatively correlated with LVEF(all P<0.001).6.The serum GDF-15 concentration in DCM group was positively correlated with LVEDD and left atrial anteroposterior diameter,but negatively correlated with LVEF(all P<0.001).Conclusions1.The serum levels of Chemerin and GDF-15 are increased in patients with DCM.The mechanism may be that Chemerin and GDF-15 promote the release of each other through the inflammatory reaction chain,and then participate in the occurrence and progression of DCM by inducing myocardial cell apoptosis and myocardial fibrosis.2.The serum level of MR-ProADM increases in DCM patients,while the mechanism may be that the increase of ventricular wall tension in DCM patients stimulates the release of MR-ProADM which plays the compensatory role by excreting water and sodium. |
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