Study On The Characteristics Of Posterior Retinal Asymmetry In Leber Hereditary Optic Neuropathy

[Purpose]The variability of posterior Pole Retinal Thickness（PPRT）was evaluated by analyzing the posterior pole asymmetry of the retina in L eber’s Hereditary Optic Neuropathy（LHON）,so as to observe the chara cteristics of posterior pole asymmetry of the retina in LHON and evalua te the clinical application value in the diagnosis of LHON.[Method]Clinical case-control study.A total of 30 cases and 60 eyes of patients with Leber hereditary optic neuropathy（LHON）with a m.11778G>A mutation locus confirmed by mitochondrial DNA testing who came to the ophthalmology department of Hubei Provincial Hospital of Traditional Chinese Medicine from November 2017 to November 2021 were selected as the Leber group,and 24 cases and 48 eyes of age-and sex-matched healthy individuals were selected as the control group at the same time in our hospital The posterior pole and macular area were scanned using the Posterior Pole mode of Heidelberg Optical Coherence Tomography（OCT）,and the posterior pole retinal thickness was examined asymmetrically in the Leber group and in the control group.The posterior polar retinal thickness topography was generated,and the posterior polar retinal thickness topography was divided into six equal areas,which were recorded as: supra-nasal area,infra-nasal area,inferior temporal area,superior temporal area,macular optic papilla area,and peripheral area;the differences in PPRT between patients with LHON and controls in different areas were compared by quantitative analysis;the characteristics of the posterior polar retinal thickness topography were compared between the Leber group and the control group,and the retinal thickness in each area（PPRT）was compared with that of the control group.The mean values of retinal thickness（PPRT）in each region were compared,and the distribution pattern and asymmetry of the changes of retinal thickness in the posterior pole of LHON were analyzed.[Results]Compared with the control group,the average thickness of the posterior polar retina in the Leber group was generally significantly thin ner,and the average thickness of the posterior polar quadrants of the re tina in the Leber group also tended to be significantly thinner compared to normal subjects,with both eyes showing the greatest change in the T5 region,which corresponds to the macular bundle region of the optic papilla;the T2 region was the second most variable,corresponding to the The T2 region was the second most variable,corresponding to the subnasal region of the posterior pole of the retina;while the T4 region showed relatively small changes;compared with the control group,the pos terior Pole Asymmetry Analysis（PPAA）in the Leber group detected by OCT posterior pole asymmetry analysis showed statistically significant di fferences（P<0.05）.with significant asymmetric changes,and the differences in the PPAA in the lower intraocular hemisphere region were statistically significant（P<0.05）,no statistically significant differences in PPAA comparisons in the intraocular upper hemisphere region（P>0.05）,and no asymmetric changes（P>0.05）;no statistically significant differences in intraocular and interocular PPAA comparisons in the control group（P>0.05）.intraocular asymmetric differences in the Leber group were all statistically significant（P<0.05）,while no statistically significant differences in interocular comparisons（P >0.05）[Conclusion]There are regional characteristics of PPRT distribution in patients with Leber hereditary optic neuropathy,and the PPAA pattern of OCT was able to detect asymmetric changes in retinal thickness in the posterior pole of LHON,and there was some asymmetry in both groups,suggesting that PPAA is helpful for the diagnosis of LHON.