Correlation Study Between Aortic Root Imaging Morphology And Age,gender As Well As Blood Pressure Based On Coronary CT Angiography

Part 1 CORRELATION STUDY BETWEEN AORTIC ROOT MORPHOLOGY AND AGE,GENDER BASED ON CORONARY CT ANGIOGRAPHYObjectives: Explore the correlation between aortic root anatomy and age,gender,by analyzing the aortic root structure size data of patients without disease.Methods: We retrospectively enrolled 3018 patients who were suspected of coronary artery disease(CAD)and underwent CCTA from June 2016 to March 2017.Subjects with heart valve disease,heart failure,congenital heart disease,cardiomyopathy,left ventricular hypertrophy,atrial fibrillation,hyper-tensioned were excluded from our study.We also excluded subjects who did not have complete clinical information,whose images couldn’t meet the acquirement of diagnosis because of motion artifacts or inadequate contrast enhancement.A total of 1286 healthy subjects(52.7±11.0 years,634 male)who underwent CCTA were retrospectively included in this study.Patients were divided into 7 groups according to age(≤30 years old;31-40;41-50;51-60;61-70;71-80;≥81 years old).Parameters of the aortic root including: aortic annulus,left ventricular outflow tract(LVOT,short and long diameter),width of the sinuses of valsalva(SOV),width of the sino-tubular junction(STJ),width of the ascending aorta and coronary ostia height was measured and compared by age and sex.Results: Normal diameters were(mean±SD): annulus short diameter: male(20.5±1.9mm)VS female(18.4±1.6mm);Annulus long diameter: male(26.9±2.1mm)VS female(23.9± 1.8 mm);Average annulus diameter: male(23.7±1.8mm)VS female(21.2±1.6mm);Left coronary ostia height: male(16.6±2.2mm)VS female(14.6±2.1mm);Right coronary ostia height: male(17.7±2.7mm)VS female(14.8±2.2mm);LVOT short diameter: male(19.4±2.4mm)VS female(17.5±2.2mm);LVOT long diameter: male(27.0±2.4mm)VS female(24.2±2.1mm);width of the SOV: male(30.7±2.9mm)VS female(27.2±2.5mm)width of the STJ :male(27.7±2.5mm)VS female(25.0±2.3mm);width of the ascending aorta: male(31.4±3.2mm)VS female(30.3±3.2mm).Aortic root parameters in males were higher than those in females in all age groups(P<0.05).Age was negatively correlated with aortic annulus dimension in male(P<0.05),while no statistical difference was found in female.Age was positively correlated with width of the SOV,width of the STJ and width of the ascending aorta regardless of gender(P<0.05).Conclusion: Significant difference in aortic root dimension was found in different age and gender.Male has larger aortic root dimension than female.Aortic annulus decreased with age,while width of the SOV,width of the STJ and width of the ascending aorta increased with age.The findings in the study could provide more parameters to guide valve design and procedure planning.Part 2 STUDY ON MORPHOLOGICAL CHANGES OF AORTIC ROOTS IN HYPERTENSIVE PATIENTSObjective: To compare the difference between the dimension of aortic root in normotensive and hypertensive patients.Methods: Retrospective analysis of 971 patients with suspected coronary artery disease underwent Coronary computed tomography angiography(CCTA).Male:165 normotensive group,mean age 52.8±10.1 years;388 hypertensive patients,mean age 53.7±10.3 years;female: 112 normotensive group,mean age 58.8±6.8 years;306 cases of hypertension,mean age 58.9±8.5 years.Diameters of aortic annulus,width of the Valsalva sinus,width of the sino-tubular junction,width of the ascending aorta of hypertensive patients were compared with those parameters of normotensive by independent t test.Results: The diameter of the ascending aorta in hypertension patients(Male: 33.2±2.8mm;Female:31.9±3.2mm)was significantly higher than normotensive patients(Male: 30.8± 3.1mm;Femmale:29.1±2.8mm)(P < 0.05),regardless of gender.Conclusion: Hypertension could induce significant dilatation of ascending aorta.