Effects Of Low Sodium Diet On Progression Of Delayed Kidney Disease:A Meta-analysis

ObjectiveThe prevalence of chronic kidney disease in the world is increasing year by year,and the kidney diseases that have occurred are irreversible.Therefore,it is essential to identify the relevant risk factors and take early intervention measures to reduce and slow down the occurrence and development of CKD.High sodium intake can lead to high blood pressure,proteinuria and fluid overload,which increases the risk of heart disease and renal deterioration in patients with chronic kidney disease.Owing to the role of the kidney in salt balance,low salt intake is considered particularly important for patients with CKD.We conducted a meta-analysis of randomized controlled trials of the effects of low-sodium diets on the progression of chronic kidney disease to explore whether changes in sodium in the diet are beneficial for CKD patients.MethodsThrough computer searching PUBMED,EMBASE and other English databases as well as China National Knowledge Infrastruture,Wanfang Database,VIP Database and China Biomedical Jouanal Literature Database,the time limit is from January 01,1996 to December 01,2018.With the themes of low sodium,chronic kidney disease,randomized controlled trials and so on,a variety of search methods were combined to screen randomized controlled studies on blood pressure,glomerular filtration rate and proteinuria in patients with chronic kidney disease treated by low sodium diet.References to relevant literature were also searched.After defining the literature,the literature is strictly screened according to the relevant standards.Two evaluators evaluate the quality of the selected literature and extract the data.If there is any disagreement,the third evaluator will evaluate them,using Revman 5.3 Software to process and analyze the data.ResultsOf the 107 articles,a total of 13(n=740)documents met the criteria,of which 11(n=498)were in English and 2(n=242)were Chinese.Meta-analysis showed that a low-salt diet could reduce systolic blood pressure by 9.11 mm Hg [95% CI(-11.04,-7.8),P< 0.001];diastolic blood pressure decreased by 4.54 mm Hg [95% CI(-5.36,-3.72),P <0.001];reduction of urinary protein by 0.55 g/d [95% CI(-0.65,-0.44),P < 0.001];no significant effect on the decline in glomerular filtration rate.ConclusionA low-salt diet can play a role in reducing blood pressure and proteinuria in patients with chronic kidney disease,but has no significant effect on glomerular filtration function(GFR).