To Study The Inflammatory Cytokines In Intracerebral Hemorrhage

ObjectiveTo investigate the significance and concentration changes of inflammatory cytokines in hematoma fluid and peripheral venous blood of intracerebral hemorrhage patients.MethodsWe measured IL-6,TNF-α,IL-1β,IL-10,IL-23 and IL-17 in hematoma fluid and peripheral blood by the method of ELISA in 40 patients with intracerebral hemorrhage.All patients were treated by the improved minimally invasive stereotactic channel surgery.31 cases of healthy control group were also involved,we used the same method to detect these inflammatory cytokines in their peripheral venous blood.t test was applied between different groups.ResultsThe concentrations of cytokines IL-6(P<0.0001),IL-1β(P<0.0001),IL-10(P<0.0001),IL-23(P<0.0001)in hematoma fluid of patients with intracerebral hemorrhage were significantly higher than that in patients’ own peripheral venous blood.In addition,the concentrations of IL-6(P<0.05)in patients’ peripheral venous blood were significantly higher than that in the control group;IL-10 was slightly increased in patients’ own peripheral venous blood.Compared with the healthy control group,IL-23 in the peripheral venous blood of the patients was slightly decreased,but there was also no statistical difference.However,there was no significant difference in the concentration of IL-17,TNF-α in hematoma fluid,patients’ own peripheral venous blood and peripheral venous blood of the control group.ConclusionIntracerebral hemorrhage can lead to the large accumulation of cytokines such as IL-6,IL-1β,IL-23 and IL-1β in hematoma fluid,and some inflammatory cytokines such as IL-6can also be increased in the peripheral circulatory system.The change of IL-23 and IL-10 is slight and more clinical data is needed.There was no significant change in the concentration of TNF-α and IL-17 in hematoma fluid as well as peripheral venous blood.