Bacterial Vaginosis Is Associated With Uterine Cervical Human Papillomavirus Infection: A Meta-analysis

Objective:The objective of this Meta-analysis of published studies is to clarify and summarize published literature on the extent to which BV is associated with cervical HPV infection.Methods:1.Search strategy :We searched PUBMED,MEDLINE,CNKI,wan fang database and reference lists of articles.Languages were restricted to Chinese and English.The articles were searched for eligible publications until September 2017.2.Selection criteria :Collect relevant literature on BV and cervical HPV infection.A detailed reading summary and the full text of the collected literature were taken,and articles that did not meet the purpose of this study or did not meet the quality requirements were excluded.The documents that meet the inclusion criteria were collated and statistically analyzed.3.Data collection and analysis:We completed the data collection,extraction and quality assessment independently.For uncertain articles and tutor consultation,determine whether to use.The included articles were analyzed using Rev Man5.3 software for statistical analysis.Results:1.Sixteen eligible studies were selected to assess the relationship between BV and HPV,including a total sample size of 9383 women,of whom 2047 were BV positive and7336 were BV negative.The pooled prevalence of BV was 31.3%.The overall estimated odds ratio(OR)showed a positive association between BV and cervical HPV infection(OR,1.69;95% confidence interval,1.33-2.13).Sensitivity analysis suggested that the results of the Meta analysis were robust,and publication bias tests did not reveal significant publication bias.2.Subgroup analysis based on income level: In low-income countries,BV was positively correlated with cervical HPV infection(OR,1.90;95% CI,1.38-2.62,P<0.05)In high-income countries,it was suggested that there was no correlation between BV and cervical HPV infection(OR,1.44;95% CI,0.98-2.10,P>0.05),the difference was statistically significant.The results suggest that the correlation between BV and cervical HPV is affected by income levels.3.Subgroup analysis based on region: in the European region(OR,1.56;95% CI,1.09-2.23,P<0.05);In the Americas(OR,2.07;95% CI,1.33-2.23,P<0.05);In the Asia(OR,1.70;95% CI,1.35-2.15,P<0.05),the difference was statistically significant.The results suggest that the correlation between BV and cervical HPV is not affected by the region.Conclusion:This Meta-analysis of available literature resulted in a positive association between BV and uterine cervical HPV infection.BV was positively correlated with cervical HPV infection.Treatment of BV is of great significance in preventing HPV infection.The correlation between BV and cervical HPV infection is not affected by the region,but it is affected by the level of income.Due to the small number of related studies,only crosssectional and cohort studies were included in the type of study,and more accurate conclusions were needed for large sample size clinical studies.