Acute Kidney Injury In Extremely Low Birth Weight Infants And Very Low Birth Weight Infants

OBJECTIVE: To evaluate and analyze the incidence,risk factors of acute kidney injury in our hospital for extremely low birth weight infants and very low birth weight infants.Provide reference for guiding early prevention and treatment of neonatal acute kidney injury(AKI).Methods: Review the hospitalization data of 250 extremely low birth weight infants and very low birth weight infants admitted to our hospital from 2015 to 2019,collecting clinical data at the time of hospitalization,mainly including the medical history data of both the mother and the newborn,and based on the diagnostic criteria of neonatal AKI,neonatal are divided into two groups: the group with AKI and the group without AKI.The clinical data are compared and analyzed.At the same time,a Logistic regression prediction model is established to analyze the possible risk factors of neonatal AKI.Result: Among the 250 premature infants with the birth weight less than 1500 g,122cases were diagnosed as neonatal AKI,and 128 cases did not develop to AKI.Compared with the group without AKI,the group with AKI have lower gestational age,birth weight,Apgar score at 5-minute,preeclampsia,maternal infection,mechanical ventilation,umbilical arteriovenous catheter placement,patent ductus arteriosus lead to neonatal AKI more easily;mechanical ventilation and umbilical arteriovenous catheter placement may be independent risk factors for neonatal AKI.Conclusion: 1.The incidence of AKI in premature infants with the birth weight less than 1500 g in our center is 48.8%,the incidence of AKI in very low birth weight infants is 47%,and the incidence of AKI in extremely low birth weight infants is 70%.2.Lower gestational age,lower weight,lower Apgar score at 5-minute,perinatal infection,preeclampsia,mechanical ventilation,umbilical arteriovenous catheter placement,patent ductus arteriosus are relate to the occurrence of neonatal AKI.Mechanical ventilation and umbilical arteriovenous catheter placement may be independent risk factors for neonatal AKI.