Clinical Study Of Buzhong Yiqi Decoction On LARS(Syndrome Of Sinking Of Qi Due To Spleen Deficiency) After Anus-preserving Surgery For Rectal Cancer

Objective:To observe the clinical efficacy and safety of treatment of Buzhong Yiqi Decoction on low anterior resection syndrome(LARS)after anus-preserving surgery for rectal cancer.Methods:A total of 66 subjects were enrolled in this study,who were recruited from the Oncology Department of the Affiliated Hospital of Chengdu University of Traditional Chinese Medicine and the Internet from January 2020 to January 2021,and were divided into the experimental group and the control group according to the random numbers generated by the serial number.The control group was treated with defecation function training,and the experimental group was treated with Buzhong Yiqi Decoction on the basic treatment in the control group.After 4 weeks of treatment,SPSS 26.0 software was used to analyze and compare the differences between the two groups in LARS grade,Bristol stool traits,TCM syndrome score,KPS score,safety evaluation grade and other aspects.Results:1.Thirty-three subjects were enrolled in the experimental group,and the study completion rate was 100%.Thirty-one subjects(two subjects fell off)were enrolled in the control group,and the study completion rate was 93.3%.2.There were no significant differences between the two groups in age,gender,histopathological classification,cancer stage,tumor cell differentiation degree,lesion site,tumor radiotherapy history,history of prophylactic ostomy,and baseline level of clinical efficacy indicators(P > 0.05).The statistical data of the two groups were comparable.3.LARS grading,stool traits,KPS score and TCM syndrome score were all improved in the experimental group after treatment(P < 0.05);After treatment,the TCM syndrome scores of "spiritlessness" and "anal swelling" were improved in the control group(P < 0.05).4.After treatment,LARS grading,KPS score,and TCM symptom curative effect of the experimental group were better than those of the control group(P < 0.05).individual scores of "anorexia","spiritlessness","defecation weakness","anus swelling" and TCM syndrome score in the experimental group are lower than those in the control group(P<0.05).5.After treatment,stool traits and individual scores of "abdominal distension","sallow complexion" in the experimental group were partially improved compared with those in the control group(P>0.05).6.According to the test indicators and the monitoring of adverse reactions in the two groups,the safety evaluation grade was Grade I.Conclusion:1.Buzhong Yiqi Decoction can improve the symptoms of LARS after anus-preserving surgery for rectal cancer,alleviate "anorexia","spiritlessness","defecation weakness" and "anus swelling",and can further improve the physical function state of patients.2.Buzhong Yiqi Decoction has good safety and no adverse reactions in the treatment of LARS after anus-preserving surgery for rectal cancer.