Clinical Observation On Treatment Of Type 2 Diabetes Mellitus With Coronary Artery Microvascular Disease(Qi Deficiency And Blood Stasis Syndrome)

Objective:By observing the improvement of the quality of life and the curative effect of TCM symptoms in patients with type 2 diabetes mellitus complicated by coronary artery microvascular disease by the method of replenishing qi and activating blood flow,the effectiveness and safety of the method of replenishing qi and activating blood in the treatment of type 2 diabetes mellitus complicated by coronary artery microvascular disease were evaluated.Methods:Patients who met the Western diagnostic criteria for type 2 diabetes and also met the diagnostic criteria for coronary microvascular disease were selected for a randomized controlled trial.Patients in both groups were actively controlled risk factors and treated for basic diseases.In addition to the above basic treatment,the experimental group was additively treated with Buyanghuanwu Decoction,the representative prescription of tonifying qi and activating blood circulation method.The observation period was 6 weeks.General indicators of patients were recorded before enrolment.The primary efficacy indexes,secondary efficacy indexes and safety indexes were recorded at the time of enrollment and 6 weeks.After the end of the trial,the changes of the main efficacy indicators,secondary efficacy indicators and safety indicators of the two groups of patients were compared.The trial data were collected and collated,and the data were input into SPSS26.0 software for analysis,and the final conclusion was reached.Results:A total of 48 qualified cases were included in the test group and 24 in the control group.Among them,2 patients in the test group took other Qi-enriching and blood-activating drugs without authorization during the test period,which affected the determination of the test results,so they were excluded.The test group had 1 A patient had some discomfort in the gastric cavity after taking Buyang Huanwu Decoction.The patient was asked to take Chinese medicine 30 minutes after meals.The patient’s symptoms were relieved and the medication was not terminated.The rest is nothing special.1.The general indicators of the two groups of subjects(including BMI,gender,age,blood pressure,glycosylated hemoglobin,etc.)were statistically analyzed before treatment,and the difference was not statistically significant.2.Main efficacy indicators: the treatment satisfaction of five items in SAQ scale in the experimental group before and after treatment and in the control group before and after treatment were P<0.01,the difference was statistically significant;At the same time,after treatment,the difference between the groups was statistically significant,P<0.01.Intra-group comparison of TCM syndrome scores between the two groups,P<0.01,the difference was statistically significant;After treatment,the difference between the two groups was statistically significant(P<0.01).3.Comparison of the efficacy of TCM symptoms: the total effective rate between the two groups was compared,P<0.01,and the difference was statistically significant.4.Comparison of secondary efficacy indicators.After treatment,the 2blood glucose and 4 blood lipids of the experimental group were compared with those before treatment,and the P value was less than 0.05,the difference was statistically significant.The cholesterol and triglycerides of the control group were compared with before treatment,and the P values were all less than 0.05,The difference was statistically significant.However,the test group was able to significantly lower the blood glucose 2h after a meal than the control group,P<0.05.There was no statistically significant difference in the residual indicators.5.During the experiment,neither the experimental group nor the control group had serious adverse reactions,and there was no abnormality in the safety indicators of the two groups of patients.Conclusion:1.Buyang Huanwu Decoction can significantly improve the quality of life and the body of the patient Functional status.2.Buyang Huanwu Decoction has the effect of lowering fasting blood glucose and 2h postprandial blood glucose,and it has a more significant effect on lowering 2h postprandial blood glucose.3.Buyang Huanwu Decoction has no obvious advantage in regulating blood lipid metabolism.4.Buyang Huanwu Decoction found no serious adverse reactions during the experiment,and it is safe for patients with type 2 diabetes and coronary microvascular disease(qi deficiency and blood stasis syndrome).