Correlation Analysis Of Neutrophil-lymphocyte Ratio And High Thrombus Load In Acute Coronary Syndrome

Background and purpose: Acute coronary syndrome is a significant subtype of coronary artery disease.Coronary intervention therapy can greatly improve the survival and prognosis of patients with acute coronary syndromes,but the high thrombotic load of infarct-related vessels will weaken the benefit of intervention therapy and even lead to the deterioration of prognosis.The neutrophil-lymphocyte ratio is a novel inflammatory marker,which has been proved by many previous studies to be closely related to the onset and prognosis of CHD.We designed this study to insure the corelation between neutrophils-lymphocytes ratio and high thrombotic load.Methods: By reviewing the hospital’s medical record system,we reviewed the PCI operation in the second Hospital of Wuxi affiliated to Nanjing Medical University in2019.A total of 349 ACS patients who met the inclusion criteria were collected.According to the situation of intracoronary thrombus,the subjects were divided into two groups: high thrombus load group(thrombus score > 2)and low thrombus load group(thrombus score ≤ 2).Using univariate analysis and multivariate analysis to confirm the correlation between neutrophil-lymphocyte ratio and thrombus score,and the receiver characteristic curve was used to explore the predictive value of neutrophil-lymphocyte ratio for high thrombotic load.Results: A total of 349 patients with acute coronary syndrome were enrolled in this study,of which 74 were in the high thrombotic load group and 275 were in the low thrombotic load group.The results of univariate analysis showed that the neutrophil-lymphocyte ratio is different between the two groups(p<0.001).After multivariate adjustment,the association is still significant(P=0.031).The best cut-off point of NLR is 4.955(sensitivity 81.1%;specificity 68.7%;AUC,0.782,95%CI,0.724-0.839).Conclusions: The neutrophil-lymphocyte ratio is closely related to the high thrombotic load in acute coronary syndrome,and has good predictive value for the high thrombotic load of ACS.