Correlation Analysis Of Risk Factors And TCM Syndrome Types Of Type 2 Diabetic Foot

Objective:Through collecting the clinical information of type 2 diabetes mellitus(T2DM)in endocrine department affiliated hospital of Chengdu University of Traditional Chinese Medicine,To explore the risk factors of type 2 diabetic foot disease(DFD)in clinical and the correlation with TCM syndrome type,Objective to provide a reference for the diagnosis and treatment of patients with type 2 diabetic foot disease.Methods:In this study,577 patients with type 2 diabetes mellitus were selected from the Department of Endocrinology,Affiliated Hospital of Chengdu University of traditional Chinese medicine from 2013 to 2020.According to the diagnostic criteria of diabetic foot,577 patients were divided into DFD group(n = 129)and NDFd group(n = 448).The general information such as gender,age,BMI,biochemical indexes such as glycosylated hemoglobin(Hb A1c),fasting blood glucose(FPG),fasting insulin(FINS),blood lipid,creatinine(Scr),uric acid(UA),BMI,course of diabetes(DD),history of hypertension and TCM Syndrome Types of the subjects were summarized.The related risk factors of DFD and the correlation between DFD and TCM syndrome types were analyzed.Rrsults:1.There were 373 males(68.21%)and 204 females(31.78%),129 in the DFD group,and 448 in the NDFD group.2.There were significant differences in age,lower extremity vascular disease history,BMI、 CRP、TC、TG、LDL-C、ALT、TBil、IBil、BUN、 Cys C,mALB between the two groups(P<0.05);there were no significant differences in gender、hypertension history、cerebral infarction history、 coronary heart disease history、DD、Hb A1c、HDL-C、FPG、FINS、FC-P、AST、DBil、Ssr、UA inorganic phosphorus between the two groups(P>0.05).3.In univariate logistic regression analysis,age、lower extremity vascular disease history、BMI、CRP、TC、TG、LDL-C、TBil、IBil、Cys C had statistical significance(P<0.05);ALT、BUN、mALB had no statistical significance(P>0.05).In multivariate logistic regression analysis,CRP、lower extremity vascular disease history、Cys C had statistical significance(P<0.05);age、BMI、TC、TG、LDL-C,TBIL、IBil、BUN、mALB had no statistical significance(P>0.05).4.The first three syndrome types of 577 cases were Qi and yin deficiency with blood stasis(55.3%),Qi and yin deficiency(17.7%),Qi and yin deficiency with phlegm and blood stasis(11.1%),phlegm dampness accumulation(8.0%),phlegm and blood stasis accumulation(4.0%),liver and kidney yin deficiency,blood stasis obstructing collaterals(2.3%),liver and kidney yin deficiency(1.2%)and kidney yin and yang deficiency(0.5%).According to the distribution of TCM syndromes,the order of DFD was Qi Yin deficiency with blood stasis syndrome(62.00%),Qi Yin deficiency with blood stasis syndrome(12.30%),phlegm and dampness accumulation syndrome(8.50%),Qi Yin deficiency with blood stasis syndrome(6.20%),phlegm and blood stasis syndrome(2.30%),phlegm and blood stasis syndrome(1.60%),kidney yin yang deficiency syndrome(1.60%).Conclution:1.There were significant differences in age、lower extremity vascular disease history、BMI、CRP、TC、TG、LDL-C、ALT、TBil、IBil、BUN、Cys C、mALB between the DFD group and NDFD group.2.History of lower extremity vascular disease/CRP and Cys C were independent risk factors for DFD.3.The most common TCM syndrome type of DFD is Qi Yin deficiency with blood stasis.