The Risk Factors And Clinical Features Of Type 2 Diabetes In Han And Tibetan Patients With Peripheral Neuropathy And The Correlation Analysis Of TCM Syndrome Types

Objective: To explore whether the risk factors for DPN in Han and Tibetan T2 DM patients are the same,and whether there are ethnic differences in the clinical characteristics of Han and Tibetan DPN,to understand the risk factors of DPN will help prevent the occurrence and development of DPN.Exploring the distribution of DPN TCM syndrome types of Han and Tibetan can provide reference for TCM dialectics of DPN patients.Methods: A total of 678 Han and Tibetan patients who were hospitalized with type 2 diabetes in the Department of Endocrinology,Affiliated Hospital of Chengdu University of Traditional Chinese Medicine,were collected from January 1,2019 to December 30,2020.Collect the name,age,course of disease,Hb A1 c,blood sugar,insulin level,C-peptide level,blood lipids and other relevant data of the above patients,and perform TCM syndrome differentiation on DPN patients.Using SPSS25.0 to analyze the data,P<0.05 was considered as statistically significant.result:1.In univariate analysis,Tibetan DPN patients’ age,course of disease,proportion of smoking patients,and Hb A1 c were higher than those of NDPN patients(P<0.05);Tibetan DPN patients had lower e GFR than NDPN patients(P<0.05).Multivariate logistic regression analysis showed that smoking,Hb A1 c,e GFR and DPN had a regression relationship.2.In univariate analysis,Han DPN patients were higher than NDPN patients in terms of age,disease course,SBP,DPVD detection rate,and hypertension(P<0.05);Han DPN patients had lower serum sodium,TBIL,and e GFR In NDPN(P<0.05).The results of multivariate logistic regression analysis showed that age,blood sodium,DPVD and DPN had a regression relationship.3.Comparing the clinical characteristics of Han and Tibetan DPN patients,Tibetan BMI,Hb A1 c,LDL-C,e GFR are higher than Han DPN patients(P<0.05),and the proportion of Tibetan patients with family history is lower than Han(P<0.05).4.Analysis of TCM syndrome types in Han and Tibetan patients with DPN(1)The majority of Han and Tibetan DPN have syndromes of phlegm and blood stasis blocking collaterals,and there is no statistical difference in the distribution of TCM syndromes between the two ethnic groups(P>0.05).(2)There was no statistically significant difference in the distribution of TCM syndrome types between Tibetan males and females.Tibetan DPN patients were the oldest with liver and kidney deficiency syndrome,which was statistically different from Qi deficiency and blood stasis syndrome(P<0.05).The BMI value of the syndrome of phlegm and blood stasis obstructing the collaterals is the largest,which is statistically different from that of qi deficiency and blood stasis syndrome(P<0.05).There was no statistically significant difference in the course of disease among the various syndrome types(P>0.05).(3)The distribution of TCM syndrome types of Han male and female DPN is statistically significant.In Han DPN patients,the course of liver and kidney deficiency was the longest,and the course of Yin deficiency and blood stasis was the shortest,which was significantly different from the syndrome of phlegm and blood stasis and liver and kidney deficiency(P<0.05).There were no statistically significant differences in age and BMI between the various syndrome types(P>0.05).Conclusion:1.There are differences in the risk factors of Han and Tibetan DPN;the clinical characteristics of Han and Tibetan DPN patients are different.2.There is no statistical difference in the distribution of TCM syndrome types between Chinese and Tibetan patients with DPN.3.Different TCM syndrome types of DPN have differences in age,disease course,and BMI.The liver and kidney deficiency syndrome has a longer course of disease and is older.The BMI value of patients with phlegm and blood stasis obstructing collaterals syndrome is higher than that of other syndrome types.