| Objective:Using retrospective research methods,116 cases of Diabetic Retinopathy(DR)patients with kidney deficiency and blood stasis type were analyzed for the related factors of TCM syndrome and renal function indexes,and the related factors of kidney deficiency and blood stasis type DR were explored,which is kidney deficiency and blood stasis type DR.The prevention and treatment provide a certain clinical basis.Methods:From April 2019 to February 2021,116 patients diagnosed with kidney deficiency and blood stasis type DR in the Ophthalmology Inpatient Department of Chengdu University of Traditional Chinese Medicine Hospital were collected from April 2019 to February 2021.The DR patients who met the inclusion criteria were divided into DR 2-4groups(observation group)),DR1 group(control group,no obvious diabetic retinopathy),a total of 61 people(122 eyes)in the observation group,including 36 males(72 eyes),25females(50 eyes),and a total of 55 people in the control group(110 Eyes),including 31males(62 eyes)and 24 females(48 eyes).The SPSS19.0 statistical software was used to retrospectively compare and analyze the general clinical data,renal function,blood lipids,blood glucose related indicators and other data information of the two groups of patients,study the differences between the two groups,and analyze the related factors of renal function indicators and kidney deficiency and blood stasis type DR The correlation between P<0.05 is considered statistically significant.Results: 1.General clinical dataThere was no statistically significant difference between the two groups of patients in age and gender(P>0.05);the prevalence of hypertension in the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05);the duration of diabetes in the observation group was higher than that of the control For group leader,the difference was statistically significant(P<0.05);the BMI value of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05).2.Blood glucose related indicators:The fasting blood glucose(FBG)and glycosylated hemoglobin(Hb A1c)of the observation group were higher than those of the control group,and the difference was statistically significant(P<0.05).3.Blood lipid related indicators:The total cholesterol(TC),triglycerides(TG)and low-density lipoprotein cholesterol(LDL-C)of the observation group were higher than those of the control group,and the difference was statistically significant(P<0.05);the observation group had high-density lipoprotein cholesterol(P<0.05).HDL-C)was lower than the control group,the difference was statistically significant(P<0.05).4.Related indexes of renal function:The urine albumin/creatinine ratio(UACR),blood urea nitrogen(BUN)and 24-hour urine protein quantitative(24h-UPr)of the observation group were higher than those of the control group,and the difference was statistically significant(P<0.05);the observation group was endogenous Creatinine clearance rate(Ccr)and glomerular filtration rate(GFR)were lower than the control group,the difference was statistically significant(P<0.05);the two groups of blood creatinine(CRE),blood uric acid(URIC),glomeruli There was no significant difference in filtration rate(GFR),serum cystatin C(Cys-C)and bloodβ2-microglobulin(β2-MG)between groups(P>0.05).5.Logistic regression analysis:(1)General clinical data: The relationship between BMI,prevalence of hypertension,course of diabetes,and DR in patients with kidney deficiency and blood stasis type diabetes was: 0.036,0.028,0.038,and the P values were all <0.05,and the difference was statistically significant;(2)Blood glucose related indicators: the relationship between glycosylated hemoglobin(Hb A1c),fasting blood glucose(FBG)and DR in diabetic patients with kidney deficiency and blood stasis type were: 0.002,0.041,all P values <0.05,the difference was statistically significant;(3)Blood lipid-related indicators: total cholesterol(TC),triglycerides(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C)and DR in patients with kidney deficiency and blood stasis diabetes The relationship P values were: 0.026,0.049,0.059,0.028,P values were all <0.05,the difference was statistically significant;(4)Renal function related indicators: urine albumin/creatinine ratio(UACR),blood urea nitrogen(BUN),endogenous creatinine clearance(Ccr),24-hour urine protein quantification(24h-UPr),glomerular filtration The relationship between GFR and DR in patients with kidney deficiency and blood stasis type diabetes were: 0.003,0.047,0.041,0.033,and 0.045,respectively,and the P values were all <0.05,the difference was statistically significant,while the high-density lipoprotein P value was 0.059,P>0.05,the difference was not statistically significant.Conclusions: 1.Kidney deficiency and blood stasis type DR has no significant correlation with the patient’s age,gender,and blood creatinine,blood uric acid,serum cystatin C,and blood β2-microglobulin.2.The related factors of kidney deficiency and blood stasis type DR are: BMI value,prevalence of hypertension,course of diabetes,urine albumin/creatinine ratio in renal function indicators,blood urea nitrogen,endogenous creatinine clearance rate,24-hour urine protein Quantitative and glomerular filtration rate as well as blood lipids and blood sugar.3.Kidney deficiency and blood stasis type DR and patients with low BMI value,high prevalence of hypertension,long course of diabetes,high urine albumin/creatinine ratio in renal function indicators,high blood urea nitrogen,high 24-hour urine protein quantitative,Low glomerular filtration rate,low endogenous creatinine clearance,high blood glucose-related indicators,and high blood lipids are closely related,which can provide a certain clinical basis for the early diagnosis and intervention of kidney deficiency and blood stasis DR.4.Detection of renal function related indicators in patients with kidney deficiency and blood stasis type DR has important clinical significance for delaying and controlling the development of DR. |
PDF Full Text Request