Analysis Of Volume Changes And Related Factors In The Brain Subregion Of Parkinson’s Disease Based On Intelligent Analysis Of MRI Imaging

Objectives:To study the changes of cerebral subregion volume with the course of disease in patients with Parkinson’s disease and the relationship between the proportion of cerebral subregion volume and related clinical factors.Methods:1.A retrospective study was conducted to collect the demographic,disease duration,personal history,past medical history,clinical examination and imaging data of PD patients who visited the Department of Neurology of China-Japan Union Hospital of Jilin University more than twice from January 2017 to December 2021 with complete clinical and imaging data.2.Import the T1-weighted axial images of cranial magnetic resonance imaging of hospitalized patients for the first time into the brain segmentation software "United Imaging Intelligence" to segment the brain tissue regions,collect the volume ratio data of brain subregions,and study the changes of the brain subregions with the course of PD patients.The relationship between spatiotemporal trajectories and volume fractions of brain subregions with general clinical data.3.SPSS 25.0 statistical software was used for statistical analysis of the data,and P<0.05 was considered statistically significant.Results:1.A total of 59 patients were enrolled in this study,including 36 males and 23 females,aged from 38 to 85 years,with onset ages from 34 to 84 years and disease course from 0.08 to 17 years.2."United Imaging Intelligence" software divides the brain into 106 substructures and collects the volume ratio data of 65 brain subregions closely related to PD.The study found that the proportion of cerebral subarea volume in left superior frontal gyrus,right superior frontal gyrus,right anterior middle frontal gyrus,left middle temporal gyrus,left paracentral lobule and left caudate nucleus decreased linearly with the increase of disease course in 59 PD patients（P < 0.05）.3.Among the 6 brain subregions that have a linear relationship with the course of PD,the left superior frontal gyrus,right superior frontal gyrus,and left paracentral lobule brain subregions in male patients accounted for less than those in female patients.Statistical significance（P<0.05）;the volume of the left superior frontal gyrus and the anterior brain subregion of the right middle frontal gyrus in patients with a history of drinking was smaller than that in patients without a history of drinking,and the difference was statistically significant（P<0.05）;The proportion of brain subregion of the left middle temporal gyrus in patients with a history of cerebral infarction was smaller than that in patients without a history of cerebral infarction,and the difference was statistically significant（P<0.05）.The proportion of volume in the subregion of the left superior frontal gyrus,the anterior part of the right frontal mid-gyrus,the left caudate nucleus,and the left paracentral lobular brain decreased with the increase of the course of the disease,and the difference was statistically significant（P<0.05）.4.Among the 6 brain subregions that have a linear relationship with the course of PD,the volume of the right middle frontal gyrus anterior brain subregion in patients with hyperuricemia is larger than that in patients without hyperuricemia,and the difference is statistically significant Significant（P<0.05）;the left superior frontal gyrus and left paracentral lobule brain subregions in patients with hypercholesterolemia accounted for more than those without hypercholesterolemia,and the difference was statistically significant（P<0.05）;The volume of the left caudate nucleus subregion in patients with hypertriglyceridemia was greater than that in patients without hypertriglyceridemia,and the difference was statistically significant（P<0.05）.5.There was no statistically significant difference in the proportion of the 6brain subregions in terms of smoking history,diabetes history,hypertension history,coronary heart disease history and hyperhomocysteinemia among the 6 brain subregions that had a linear relationship with PD course（P > 0.05）.Conclusion:1.With the increase of the course of disease,the proportion of cerebral subregions such as left superior frontal gyrus,right superior frontal gyrus,right anterior middle frontal gyrus,left middle temporal gyrus,left paracentral lobule and left caudate nucleus tended to linearly atrophy in PD patients,and these atrophic brain regions may become potential imaging markers for the early diagnosis of PD.2.Cerebral infarction and alcohol consumption may accelerate the progression of PD,while smoking,hypertension,diabetes and coronary heart disease have no significant influence on the progression of PD.3.Hyperuricemia,hypercholesterolemia and hypertriglyceridemia may have protective significance for the development of PD;There was no significant effect of hyperhomocysteine on PD progression.