Study Of The Relationship Between Serum IL-1β And IL-18 Content With Diurnal And Nocturnal Blood Pressure Rhythm In Primary Hypertension

Objective:By determining two inflammatory factors—IL-1β and IL-18 in the serum of patients with primary hypertension,and analyze the results of ambulatory blood pressure monitoring（ABPM）to explore whether and how these 2 inflammation factors are related to the blood pressure circadian rhythm.To provide more clues for the research on the relationship between diurnal and nocturnal rhythm fluctuations of blood pressure and internal environmental inflammation in patients who suffer from primary hypertension.Simultaneously,we hope it can offer more ideas for reasonable prevention and treatment of primary hypertension.Methods:Primary hypertension patients who received treatment in the Department of Cardiology of the Nanhu branch court from Jul.2021 to Dec.2021 were selected as the observation group,people who received health examination in the same time period was selected as the control group.The contents of IL-1β and IL-18 were determined by ELISA.At the same time,we performed ABPM to research objects.According to the ABPM results,the blood pressure rhythm was divided into 3 groups: shallow dipper,dipper,and reverse dipper,dipper blood pressure rhythm will be considered to normal rhythm type,and non-dipper to abnormal types.Use statistical methods to process information about these 2 inflammation factors content and different diurnal and nocturnal blood pressure rhythm types.Then discuss the relationship between the content of serum inflammatory factors and the diurnal and nocturnal rhythm of blood pressure.Results:This study included 55 patients in the observation group and 30 people who received health examination in the control group.There were no statistically significant differences in age,gender,BMI and smoking history between the observation group and the control group（P >0.05）.Compare to the incidence of abnormal blood pressure circadian rhythm over 2 groups,and the incidence of abnormal rhythm in the observation group was significantly higher than control group（P <0.05）.The serum IL-1β content in the patient group was higher than that in the control group（P <0.05）.However,there was no significant difference in serum IL-18 content between these 2 groups（P >0.05）.The blood pressure rhythm in the observation group was further analyzed for the levels of 2 inflammatory factors in serum of the patients in the dipper,shallow dipper and reverse dipper type.The difference of IL-1β content between3 rhythm types was statistically significant（P <0.05）,but the IL-18 content has no statistical difference（P >0.05）.The Spearman rank correlation analysis was further carried out,and it is concluded that the serum IL-1β content have positive hierarchical correlation with circadian rhythm disorder of blood pressure（r=0.486,P <0.05）.Conclusion:1.The increase of serum IL-1β content is related to the abnormal change of blood pressure rhythm in patients who suffer from primary hypertension,and there is a positive correlation with the degree of rhythm disorder.IL-1β in the internal environment may be a risk factor for the occurrence and aggravation of blood pressure rhythm disorders in patients.IL-1β is expected to provide reference for the diagnosis,treatment and management of primary hypertension.2.In clinical situations,the content of IL-18 cannot be considered that it is related to whether or not the rhythm of blood pressure is disordered and how disorder degree is in patients.