Analysis Of Lipid Levels And Related Risk Factors In Patients With Cerebral Hemorrhage

Objective:Cerebral hemorrhage（ICH）is a common form of severe stroke and its risk factors have been extensively studied,but the risk factors may not be completely consistent across age groups.The purpose of our study was to provide guidance for the treatment and secondary prevention of patients with cerebral hemorrhage at different ages by comparing and analyzing the risk factors for cerebral hemorrhage in patients at different ages.Methods:A total of 414 patients with spontaneous cerebral hemorrhage who were admitted to the Department of Neurology and Department of Neurosurgery at Sino-Japanese Friendship Hospital of Jilin University from October 2019 to January 2022 were selected.Age,gender,history of hypertension,history of diabetes,history of coronary heart disease,history of atrial fibrillation,history of stroke,history of smoking,history of alcohol consumption,history of antiplatelet aggregation drugs and anticoagulant drugs,BMI,platelet count,ALT,AST,GGT,triglycerides（TG）,serum total cholesterol（TC）,high-density lipoprotein（HDL）,low-density lipoprotein（LDL）,apolipoprotein A1（apo A1）,apolipoprotein B（apo B）,apolipoprotein E（apo E）,lipoprotein a（Lp（a））,blood uric acid,blood homocysteine,and creatinine.And all patients were divided into 3 age groups according to the latest WHO classification criteria for age groups:youth group: 18-44 years old,middle-aged group: 45-59 years old,and elderly group: 60-85 years old.The IBM SPSS26.0 software package was used for statistical analysis of the data.After assigning the variables,the count data were subjected to a multi-line,multi-column chi-square test,and the statistically different count data were then analyzed between groups;all quantitative data were tested for normality using Kolmogorov-Smirnov,and the measures that conformed to a normal distribution were subjected to a t-test,and the trend of the distribution was described by M（P25,P75）to describe the trend of the distribution.The test level was P<0.05 to analyze and discuss the differences in risk factors in patients with cerebral hemorrhage in different age groups.Results:1.Among all patients with cerebral hemorrhage included in this study,77.8% were male.The most significant risk factors were hypertension（64.5%）,overweight or obesity（59.9%）,smoking（39.6%）,and alcohol consumption（28.3%）,respectively.The first risk factor in the youth group was overweight or obesity,while the first risk factor in both the middleaged and elderly groups was hypertension.2.The levels of HDL and apo A1 were lower in the youth group relative to the middle and elderly groups（P<0.05）,while the levels of TG,TC,LDL,and apo B were higher in the youth group relative to the other two groups（P<0.05）.HDL levels were higher in the older group than in the other two groups（P<0.05）.3.Compared with the middle-aged and elderly groups,the young group had a higher incidence of platelet count,ALT,GGT,uric acid,creatinine levels,overweight or obesity than the other two groups（P<0.05）,a lower incidence of history of antiplatelet aggregation or anticoagulant application,and history of cerebral infarction than the other two groups（P<0.05）,and its proportion of male patients was higher than that of the middle-aged group（P<0.05）.Blood homocysteine levels were higher in the elderly group than in the other two groups（P<0.05）,and the incidence of coronary heart disease was higher than in the middle-aged group（P<0.05）.The incidence of overweight or obesity was higher in the middleaged group than in the elderly group（P<0.05）.Conclusion:1.The most common risk factors for cerebral hemorrhage are hypertension,overweight or obesity,smoking,and alcohol consumption.The first risk factor for cerebral hemorrhage in young people is overweight or obesity,and the first risk factor for middle-aged and elderly patients is hypertension.2.Lower levels of TG,TC,LDL,and apo B may somewhat increase the incidence of cerebral hemorrhage in middle-aged and elderly people,while low levels of HDL and apolipoprotein A1 may increase the risk of cerebral hemorrhage in young people.3.High blood homocysteine is a key factor in elderly patients with cerebral hemorrhage.4.Higher levels of platelet count,ALT,GGT,uric acid,and creatinine are associated with the development of cerebral hemorrhage in young people.