Effects Of Sleep Disordered Breathing During Pregnancy On Pregnancy

Objective 1.To explore the risk factors of sleep disordered breathing;2.Analyze the possible adverse maternal and infant outcomes caused by sleep disordered breathingMethods1.Information of 88 pregnant women who underwent obstetric examination in chaohu Hospital affiliated to Anhui Medical University from August 2020 to March 2021 was randomly collected.According to the inclusion criteria,84 valid data were obtained,and they were divided into the snoring group and the normal group according to whether there was snoring.A modified Berlin Questionnaire score was given to pregnant women,and the snoring group can be divided into two groups: low risk OSA group and high risk OSA group.By the time of termination of pregnancy,69 data with complete information were available due to incomplete information of pregnant women.According to whether or not snoring existed at this time,they were divided into snoring group and normal group.The modified Berlin Questionnaire score was given again,and the snoring group was divided into low-risk OSA group and high-risk OSA group.The same method was used to analyze the data of 69 patients with snoring and normal snoring in early pregnancy,as well as the data of low-risk OSA and high-risk OSA in snoring group.2.The data with complete information is composed of maternal data and fetal data,including maternal age,weight before pregnancy,weight at termination of pregnancy,and Body Mass Index before pregnancy,BMI at termination of pregnancy,weight gain during pregnancy,termination of pregnancy termination of pregnancy gestational age,the number of pregnancy,abortion,cesarean delivery times,termination of pregnancy,the pregnancy complications during pregnancy（gestational hypertension disease,gestational diabetes,liver damage,etc.）and pregnancy complications（pregnancy with anemia,pregnancy with hypothyroidism）etc.;Fetal data included gestational age,birth weight,Apgar score and S/D ratio.Make a reasonable analysis of the data.Results1.During the first trimester and the third trimester of pregnancy with complete data,27（39.13%）women had snoring in the first trimester group,42（60.87%）in the normal control group,45（65.22%）in the third trimester group and 24（34.78%）in the normal control group.As a result,new snoring occurs as pregnancy progresses,and the number of women with snoring increases significantly by the third trimester.2.During the data analysis of pregnant women with complete data,the screening rates of OSA in the low-risk OSA group and high-risk OSA group in the early and late trimesters were 25.93% and 55.56%,respectively,using the modified Berlin Questionnaire.Therefore,the modified Berlin questionnaire is more sensitive in screening high-risk OSA in the third trimester.3.Comparison of maternal data in the first trimester and the third trimester respectively（1）Comparison of general data of all pregnant women with snoring in the early pregnancy group and the normal control group: there were no significant differences between the snoring group and the control group in age,previous pregnancy times,previous number of cesarean section,previous history of abortion,previous number of abortion（P>0.05）.There were statistically significant differences in prepregnancy weight and BMI between snoring group and normal control group（P<0.05）.（2）Comparison of the general data of all pregnant women with early pregnancy snoring in the low-risk OSA group and high-risk OSA group: there were no significant differences in age and number of previous abortions between OSA group and OSA group（P>0.05）.There were statistically significant differences in prepregnancy weight and BMI between high-risk OSA group and low-risk OSA group（P<0.05）.（3）Comparison of pregnant women with snoring in the third trimester group and normal control group:There were no significant differences in age,weight at birth,BMI at birth,weight gain during pregnancy,number of pregnancies,gestational week at termination of pregnancy,mode of delivery,pregnancy complications,pregnancy complications,gestational age,birth weight,apgar score and S/D ratio between snoring group and normal control group（P>0.05）.（4）Comparison of pregnant data between OSA group and OSA group during the third trimester of pregnancy: there were no significant differences between OSA group and OSA group in weight gain,gestational week at termination of pregnancy,pregnancy complications,fetal age,fetal birth weight,fetal APgar score and S/D ratio（P>0.05）.There were statistically significant differences in age,weight at birth,BMI at birth,number of pregnancies,mode of delivery and incidence of pregnancy complications between high-risk OSA group and low-risk OSA group（P<0.05）.（5）The correlation analysis between age body mass index（BMI）and OSA risk grade in pregnant women with snoring in the third trimester showed that OSA risk grade was closely related to BMI and pregnancy（P<0.05）.Conclusions1.With the progress of pregnancy,there are more pregnant women with SDB in the third trimester of pregnancy,and its clinical manifestations are more prominent.At this time,questionnaire screening is more sensitive.2.The differences in body weight and BMI among pregnant women with SDB during pregnancy were always statistically significant,suggesting that body weight and BMI may be independent risk factors for pregnant women with SDB during pregnancy,and this situation was more specific in pregnant women in early pregnancy.At the same time,pregnancy or parturient women may also be related factors to increase the risk of OSA,which still needs to be confirmed by further studies.3.SDB has a greater impact on pregnant women than on the fetus,and significantly increases the incidence of cesarean section,gestational diabetes and hypertensive diseases during pregnancy.