| Objective Quantitative magnetic susceptibility map（QSM）was used to quantify the iron deposition in the deep gray matter nuclei of primary grade 1 hypertension and normal control group.To discuss the relationship between patients with primary grade 1 hypertension and normal control group with age,gender and iron deposition in deep gray matter nuclei;To compare the difference of iron deposition in deep gray matter nuclei between primary grade 1 hypertension and normal control group,and analyze the difference between primary grade 1 hypertension and normal control group.Discuss the value of QSM in the research and application of hypertension,summarize the characteristics of iron deposition in deep gray matter nuclei of patients with primary grade 1 hypertension and normal control group,and provide scientific imaging evidence for further exploring the pathogenesis of hypertension and the treatment and prevention of hypertension.Methods This study prospectively collected two groups of age-matched and gender matched subjects from the first people’s Hospital of Yunnan Province.The subjects were divided into:（1）27 patients with primary grade 1 hypertension（PG1H,11 men,16 women;average age 49.9 ± 4.1 years）and（2）27 normal controls（HC,12 men,15 women,average age 50.3 ± 5.5 years）.All subjects used German Siemens PRISMA 3.0T magnetic resonance scanner and 20 channel head neck combined coil to scan the routine sequence of skull MRI and QSM sequence.Use the MEDI toolbox on the data analysis software MATLAB to post process all 128 original amplitude images and original phase images,and finally calculate 64 QSM images.At the best level of displaying the deep gray matter nuclei of the brain,the ROI regions of bilateral globus pallidus,red nucleus,substantia nigra,thalamus,caudate nucleus and cerebellar dentate nucleus were manually drawn with mricron drawing software,and the sensitive values of ROI regions were obtained and recorded.The collected data were statistically analyzed by statistical software SPSS 25.0,and the measured data were expressed by mean ± standard deviation（Mean ± SD）.Two independent samples t-test was used to compare and analyze the differences of magnetic sensitivity values of target deep gray matter nuclei between normal control group and primary grade 1 hypertension group in different ages,general data and gender;Paired t-test was used to compare and analyze the difference of magnetic sensitivity between the left and right of the deep gray matter nuclei of the target brain in the primary grade 1 hypertension group and the normal control group;Pearson correlation analysis was used to analyze the correlation between iron deposition in deep gray matter nuclei of primary grade 1 hypertension group,normal control group and the above six groups,and the correlation between magnetic sensitivity and age of deep gray matter nuclei of the six groups;The correlation between the deep gray matter nuclei of the above six groups in the primary grade 1 hypertension group and the normal control group was analyzed;Select the representative areas of deep brain gray matter nuclei in statistical analysis for further analysis,make ROC curve,and determine the area under the curve and the best diagnostic boundary value.P < 0.05,the difference was considered to be statistically significant.Results The results showed that there was no correlation between iron deposition in the deep gray matter nuclei of the target brain and age in the six groups of normal control group（P > 0.05）;In the normal control group,there was no difference in iron deposition in the target deep gray matter nuclei between subjects ≤ 50 years old and subjects > 50 years old（P > 0.05）;In the primary grade 1 hypertension group,the substantia nigra R of subjects ≤ 50 years old was different from that of subjects > 50 years old（P = 0.032）.The substantia nigra R of subjects ≤ 50 years old（25.59 ± 2.44）ppm was higher than that of subjects > 50 years old（23.58 ± 2.14）ppm;In primary grade 1 hypertension group,there was a low-intensity negative correlation between age and right cerebellar dentate nucleus（r =-0.405,P = 0.036）,while there was no correlation between target deep brain nucleus and left cerebellar dentate nucleus and age in the other five groups;There was no correlation between iron deposition in deep gray matter nuclei of target brain and gender in 6 groups of normal control group（P > 0.05）;The substantia nigra L of men was different from that of women（P = 0.003）.The substantia nigra L of men（26.64 ± 3.08）ppm was higher than that of women（23.19 ± 2.35）ppm;The substantia nigra R of men was different from that of women（P = 0.023）.The substantia nigra R of men（25.90 ± 2.25）ppm was higher than that of women（23.74 ± 2.29）ppm;The thalamus L of men was different from that of women（P = 0.002）.The thalamus L of men（13.98 ± 1.34）ppm was higher than that of women（12.26 ± 1.17）ppm;The thalamic R of men was different from that of women（P = 0.033）.The thalamic R of men（13.37 ± 1.42）ppm was higher than that of women（11.96 ± 1.70）ppm;The target deep gray matter nuclei in the 6 groups of primary grade 1 hypertension were higher than those in the normal control group（P < 0.001）,especially in the red nucleus,globus pallidus and substantia nigra,followed by thalamus and cerebellar dentate nucleus,and finally caudate nucleus;There was no significant difference between the left and right sides of globus pallidus,red nucleus,substantia nigra,thalamus,caudate nucleus and cerebellar dentate nucleus in the control group and primary grade 1 hypertension group（P > 0.05）.Conclusions In this study,QSM was used to preliminarily explore the characteristics of brain iron deposition in patients with primary grade 1 hypertension,further deepen the understanding of the physiological and pathological changes of hypertension,provide a new entry point and follow-up research ideas for clinical understanding of the pathogenesis of hypertension,and provide an objective,useful and reliable imaging basis for the clinical diagnosis and follow-up treatment of hypertension;As the best magnetic sensitive sequence for noninvasive quantification of iron deposition in various human tissues and organs,QSM has high scientific research and clinical application value in the evaluation of hypertensive brain iron deposition. |
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