| Objective:C-type lectin-like receptor 2（CLEC-2）is a platelet activating receptor based on tyrosine activation motif of immune receptor,which can participate in platelet activation and aggregation by binding to its ligands.This physiological process can prevent the body from excessive blood loss,but ti is also the pathological basis of many thromboembolic diseases.Therefore,this study intends to investigate the changes of plasma CLEC-2 levels in different disease severity groups,and to compare the plasma CLEC-2 levels in the cerebral artery stenosis group and the non-cerebral artery stenosis group.The purpose of this paper was to explore the relationship between plasma CLEC-2 levels and the severity of acute cerebral infarction and cerebral artery stenosis.Methods:211 patients with acute cerebral infarction who were hospitalized for the first time in the Department of Neurology of The Second People’s Hospital of Lianyungang city from June 2020 to July 2021 were prospectively selected as the infarction group.According to the National Institutes of Health Stroke Scale score at the time of admission,all patients were divided into three subgroups: mild,moderate and severe;According to the results of cranial MRA examination,they were divided into cerebral artery stenosis group of 122 cases and no stenosis group of 89 cases;During the same period,105 healthy subjects in our hospital were selected as the control group.Venous blood was collected from all patients on the day of admission for CLEC-2 detection,and the levels of CLEC-2 between groups were compared.Baseline data（age,gender,BMI,past medical history）,NIHSS scores,and laboratory test results（total cholesterol,low-density lipoprotein,fasting blood glucose,blood homocysteine,and uric acid,etc.）were collected for all subjects.SPSS23.0 software was used for data processing,P<0.05 was statistically significant.Results:1.The level of plasma CLEC-2 in the infarction group（269.34±68.55pg/m L）was significantly higher than that in the control group（172.98±21.01pg/m L）（P<0.001）,the level of CLEC-2（OR1.042,95%CI1.029-1.055,P=0.000）was an independent risk factor for acute cerebral infarction;2.The levels of CLEC-2 in the mild,moderate and severe subgroups of acute cerebral infarction were 226.55±48.51pg/m L,323.23±28.72pg/m L,359.09±29.75pg/m L,and the CLEC-2 levels gradually increased.The difference was statistically significant（P<0.001）.Spearman correlation analysis showed that plasma CLEC-2 levels were positively correlated with NIHSS scores（r=0.881,P=0.000）;3.Univariate analysis showed that CLEC-2 was associated with cerebral artery stenosis（305.55±53.38pg/m L VS 219.70±54.65pg/m L,P=0.000）;after adjusting for confounding factors,multivariate Logistic regression analysis showed that BMI（OR1.453,95%CI1.122～1.881,P=0.005）,age（OR1.078,95%CI1.032～1.126,P=0.001）,fibrinogen（OR2.159,95%CI1.191～3.915,P=0.011）and CLEC-2concentration（OR1.034,95%CI1.020-1.048,P=0.000）were independent risk factors for cerebral artery stenosis in patients with acute cerebral infarction.Receiver operating characteristic（ROC）curve analysis showed that the area under the curve of CLEC-2 for predicting cerebral artery stenosis was 0.862（95%CI: 0.812-0.912,P<0.001）;the best cut-off value was 266.40pg/m L,predicting The sensitivity of cerebral artery stenosis was 80.3%,and the specificity was 80.9%.Conclusion:1.Plasma CLEC-2 levels are significantly correlated with acute cerebral infarction,and can be used as an independent risk factor for acute cerebral infarction;2.Plasma CLEC-2 level can be used as an indicator for evaluating the severity of acute cerebral infarction;3.Plasma CLEC-2 level is an independent risk factor for cerebral artery stenosis, and has certain value in predicting cerebral artery stenosis. |
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