Diagnostic Value Of ROMA And CPH-I In Early Epithelial Ovarian Cancer

Objective This paper aims to investigate the diagnostic value of ROMA and CPH-I in early epitheial ovarian cancer（EOC）.Methods A total of 139 patients with epitheial ovarian tumor,including 52 patients with early EOC,24 patients with borderline ovarian tumor（BOT）and 63 patients with epitheial benign ovarian tumor,who were admitted to our hospital from January 2018 to December 2020,were selected to conduct a retrospective study.EOC is staged according to International Federation of Gynecology and Obstetrics（FIGO）2014 standard.Age,menopausal status and serum human epididymis protein 4（HE4）and carbohydrate antigen125（CA125）values of all the selected patients were collected and the predicted probabilities of ROMA and CPH-I are calculated.Area under the curve（AUC）is calculated by receiver operating characteristic curve（ROC）to measure the diagnostic accuracy of these indicators and the sensitivity,specificity,positive predictive value,negative predictive value of CA125,HE4,ROMA and CPH-I in each group were calculated.Results 1.Age and the proportion of postmenopausal women in the early malignant group were higher than those in the benign group,and the difference was statistically significant（P<0.05）.2.The AUC of CPH-I,ROMA and HE4 was superior to that of CA125 in all groups.The results of intergroup comparison showed that CA125,HE4,ROMA and CPH-I were early malignant group>borderline group>benign group,and the differences were statistically significant（P<0.001）.3.ROMA and CA125 are more sensitive than CPH-I and HE4 in predicting benign or malignant ovarian neoplasms（92.31%、88.46% vs 86.54%、82.69%）.CPH-I and HE4 were more specific than ROMA and CA125（96.83%、93.65% vs 90.48%、76.19%）.4.When groupd by menopausal status,the AUC of ROMA,CPH-I and HE4 was higher than that of CA125,regardless of menopausal status.In the comparison between the benign group and the early malignant group,among postmenopausal women,ROMA and CPH-I have the highest positive predictive value and negative predictive value（96.77%、95.83%）,and the ROMA and CPH-I of postmenopausal patients have higher AUC,sensitivity and specificity than premenopausal patients（0.995、0.992 vs 0.905、0.935,96.77%、96.77% vs85.71%、71.43%,95.83%、95.83% vs 87.18%、94.87%）.Conclusion 1.In early diagnosis of EOC,ROMA has better sensitivity,and the specificity of CPH-I is superior to ROMA.2.ROMA and CPH-I have better sensitivity and specificity in postmenopausal patients.3.Among postmenopausal women,ROMA and CPH-I have the highest positive predictive value and negative predictive value in the comparison between the benign group and the early malignant group.