Effects Of Vitamin Deficiency On Pregnant Women And Newborns

Objective:By investigating the level of vitamin D in midpregnancy and umbilical cord blood serum of pregnant women,understanding the current status of vitamin D deficiency in pregnant women in this area,to investigate the effect of vitamin D deficiency on pregnant women and newborns,scientifically guiding pregnant women to rationally supplement vitamin D to improve adverse pregnancy outcomes.Methods:From September 2020 to September 2021,383 pregnant women who had established archives standardized prenatal examinations and childbirth in the First Hospital of Lanzhou University were randomly selected as subjects.Through questionnaire and view the history data acquisition pregnant women basic information（age,nationality,pregnancy weight and weight gain during pregnancy,maternal history,etc.）and check in the process of inspection items,have definite diagnosis without pregnancy complications,and information about pregnant women and newborns at the time of delivery and outcomes of newborns after delivery.According to the level of 25（OH）D in midpregnancy and umbilical cord blood,pregnant women were divided into vitamin D sufficient group,vitamin D insufficient group and vitamin D deficient group,among which vitamin D deficiency could be divided into mild vitamin D deficiency and severe vitamin D deficiency.The incidence of neonatal and maternal adverse pregnancy outcomes and the body length and head circumference of newborns in each group was compared.SPSS 22.0 software was used for data analysis.The main methods include an OVA for comparison of quantitative data and Chi-square test for qualitative data analysis of two groups.Descriptive content gives the number and percentage of cases,mean and standard deviation.Results:1.In 383 pregnant women,the average level of 25（OH）D sufficient group,insufficient group,mild deficiency group and severe deficiency group were（35.61±5.80）ng/ m L,（23.58±2.65）ng/ml,（14.05±2.74）ng/ml,（7.48±1.6）ng/ml,respectively.The incidence of vitamin D deficiency in pregnant women in the second trimester was about 79.7%,and 14.4% for vitamin D insufficient.Only 6% of pregnant women’s 25（OH）D level was in the normal range.The levels of 25（OH）D insufficient group,mild deficiency group and severe deficiency group were（21.19±0.71）ng/ml,（15.02±2.94）ng/ml and（9.31±0.84）ng/ml,respectively.The incidence of vitamin D insufficient in cord blood was about 19.8%.The incidence of vitamin D deficiency was about 80.1%.2.Vitamin D deficiency was not associated with the risk of neonatal outcomes such as preterm birth,low birth weight,neonatal sepsis,and neonatal asphyxia,and did not affect the head circumference and body length of newborns at birth.3.Low concentrations of 25（OH）D in pregnant women did not increase the risk of adverse pregnancy outcomes such as gestational diabetes mellitus and gestational hypertension.Conclusions:1.Vitamin D levels in pregnant women and newborns are generally low,and the incidence of vitamin D deficiency in pregnant women and newborns in the second trimester of pregnancy is very high.2.There was no significant correlation between vitamin D deficiency and neonatal outcome or adverse pregnancy outcome.3.Decreased vitamin D levels did not adversely affect head circumference and length at birth.