Correlation Between IS/OS Layer And Visual Recovery In The Treatment Of Idiopathic Macular Epiretinal Membrane By Internal Limiting Membrane Peeling

Objective: To explore the efficacy and safety of internal limiting membrane peeling in the treatment of idiopathic macular epiretinal membrane and the correlation between IS/OS layer and visual recovery.Methods: The clinical data of34 patients with iERM who underwent surgical treatment in our hospital from June2017 to June 2021 were retrospectively analyzed.The selected patients were determined according to the inclusion criteria and exclusion criteria.According to the connection of IS/OS layer on preoperative macular OCT images,they were divided into two groups: Patients with normal IS/OS layer（group A）and patients with interrupted IS/OS layer（group B）.To analyze the efficacy of internal limiting membrane peeling in the treatment of idiopathic macular epiretinal membrane,and the correlation between preoperative IS/OS connection,preoperative CMT thickness and postoperative visual acuity recovery.Results: after the correction of the number of cases,t-test was used for the data between the two groups,repeated measurement analysis of variance was used for the data within the group,and Pearson test was used for the correlation.The results were as follows: preoperative BCVA in the two groups（group A: 0.74 ± 0.34,group B: 1.12 ± 0.61,P = 0.03）;One month after operation（A:0.69 ± 0.21,P = 0.44;B: 0.98 ± 0.44,P = 0.57）,three months after operation（A: 0.49± 0.17,P = 0.03;B: 0.70 ± 0.19,P = 0.08）,six months after operation（A: 0.39 ± 0.17,P < 0.01;B: 0.59 ± 0.14,P = 0.03）;There were statistically significant differences at3 months and 6 months after surgery.And there was an increasing trend in one month and three months after operation in group B,But there was no statistical difference.Six months after operation was significantly higher than that before operation;There were significant differences in the best corrected visual acuity before and after operation between the two groups（P < 0.05）.There was no significant difference in preoperative CMT,postoperative one-month CMT,postoperative three-month CMT and postoperative six-month CMT between the two groups（P > 0.05）;Compared with preoperative CMT,CMT in the two groups decreased significantly in one month,three months and six months after operation（P < 0.05）.The macular structure of the two groups improved in varying degrees after operation.There was no correlation between preoperative CMT and Pearson analysis of best corrected visual acuity six months after operation in the two groups（P > 0.05）.Conclusion: internal limiting membrane peeling is effective in the treatment of idiopathic macular epiretinal membrane.BCVA and macular structure are improved in both groups six months after operation,and the postoperative best corrected visual acuity is closely related to the connection of IS/OS layer,but the preoperative CMT has nothing to do with the postoperative best corrected visual acuity.Conclusion: internal limiting membrane peeling is effective in the treatment of idiopathic macular membrane,and the postoperative best corrected visual acuity is closely related to the understanding of IS/OS layer,and the preoperative CMT has nothing to do with the postoperative best corrected visual acuity.