Research On High-performance Medical Hydrogel Nanocomposites

Hydrogel is a functional polymer material with a three-dimensional network structure.The polymer network structure contains a large number of hydrophilic groups,such as hydroxyl,carboxyl,amide and etc.It can absorb water or solution hundreds or even thousands times of its own weight.Even under pressure,it may still maintain its good water absorption and water retention.Hydrogels are often used as scaffolds for tissue engineering,drug delivery tools,optical and fluidics brakes,and biological materials that mimic extracellular matrices.However,due to the poor mechanical properties of hydrogels,their application is largely limited.Studies have shown that one of the most promising strategies for improving the mechanical properties of hydrogels is to incorporate inorganic nanomaterials such as graphene oxide(GO),carbon nanotubes(CNT)into hydrogels to prepare polymer/inorganic nanocomposites.In this paper,nanocomposites with good mechanical properties were prepared by using graphene oxide,graphene oxide/carbon nanotube composites as enhancing agents.Specific works includes the followings:1.Four different graphene oxides were prepared respectively by Hummers method,Hummers method with excess KMnO4,Hummers method with extended reaction time,and Hummers method adding H3PO4.Studies have shown that graphene oxide prepared by Hummers method adding H3PO4 has a greater degree of oxidation,and a more regular structure than other GO samples,which indicating that this method is propitious to the large-scale production of GO.2.Graphene/carbon nanotube composite nanomaterials were synthetised through amidation reaction.The prepared GO/CNT nanocomposites have good three-dimensional structure and super high surface area,effectively reducing the accumulation of GO and CNT.Due to its unique microstructure and excellent thermostability,the nanocomposite has a good application prospect in biomedicine,conductive thin films,and energy storage.3.The GO/CNT-Fe3O4 composites were prepared by attaching Fe3O4 nanoparticles of uniform size on GO and CNT through simple mechanical mixing method.The incorporation of Fe3O4 nanoparticles endows the material an important targeting function.Moreover,composite materials can effectively reduce the aggregation of iron oxide and increase the adsorption sites,which enhances the targeted transfer effect of the material.4.GO/CNT nanocomposite hydrogel with excellent mechanical properties and good biocompatibility was prepared by in-situ one-pot free radical polymerization.GO/CNT was used as a filler to enhance the hydrogel’s mechanical properties,AAc and AAm were used as matrix to improve the hydrogel’s biocompatibility.The effects of initiators,crosslinkers,and GO/CNT ratios and concentrations on the hydrogel during the reaction were studied.Through a series of experimental characterizations,it was demonstrated that the prepared GO/CNT hydrogels have better thermostability,excellent mechanical properties and good biocompatibility.At the same time,GO hydrogels were also prepared.By comparison,GO/CNT nanocomposite hydrogels are superior to GO nanocomposite hydrogels in structural and mechanical properties.