Comparative Analysis Of TCM Syndrome Distribution And Related Influencing Factors Between Alzheimer's Disease And Vascular Dementia

Objective:This research mainly analyzes and compares the general situation and TCM syndrome of patients with mild and moderate Alzheimer’s disease(AD)and vascular disease(VD),so as to provide objective data for the precise differentiation of dementia and provide method for the precise treatment of dementia with traditional Chinese medicine.Methods:The design of this research adopted cross-sectional survey method.The diagnostic criteria for dementia referred to the fourth edition(DSM-Ⅳ)of the American Handbook on the diagnosis and Statistics of Mental Diseases.AD diagnostic criteria referred to the National Institute of Aging and Institute of Aging and the Alzheimer’s Association(NIN-AA),revised in 2011.VD diagnostic referred to the criteria of the National Institute of Neurology and Stroke Conference on Neuroscience Research(NINDS-AIREN).This study included 349 patients with mild and moderate dementia.There were 146 patients in AD group and 209 in VD group.This research collected the information of sex,age,case collection place,combined disease,bad living habits,dementia degree,TCM syndrome.This study used Excel tables to establish a database,records all data,and uses SPSS26.0software for statistical analysis.If the measurement data were from normal distribution,the independent sample T test method was adopted.The counting data were tested byχ~2,and the grade data were tested by non-parametric Mann-Whitney U.This research analyzed the distribution differences of demographic factors,combined history,bad living habits,case collection place,TCM syndromes in AD group and VD group.Result:1.There was no significant difference in gender,age,education level between AD group and VD group when considering demographic factors(P>0.05).2.Considering bad living habit,patients with smoking and drinking habit in VD group were more than AD group(P<0.05),but there was no significant difference in dementia degree(P<0.05).3.The number of patients with hypertension,atherosclerosis,diabetes and hyperlipidemia VD is more than AD group(P<0.05).VD group had more patients with 3 or more comorbidity than AD group(P<0.05).4.The number of VD groups in Hunan Academy OF Traditional Chinese Medicine Affiliated Hospital and Changsha Xiangheng Rehabilitation Hospital was more than that in AD group(P<0.05).The number of AD groups in Changsha Carnation Geriatric Hospital and Wangjianglou apartment for the elderly was more than that in VD group(P<0.05).Changsha Xiangheng Rehabilitation Hospital has more moderate dementia patients(P<0.05).5.The Comparison of TCM Syndrome(1)Considering simple syndromes,there were significant differences between AD group and VD group in spleen deficiency,yin deficiency,yang deficiency,yang hyperactivity,phlegm turbidity and blood stasis syndrome(P<0.05).VD group had high incidence of yin deficiency syndrome,yang hyperactivity and blood stasis.AD group had high incidence of spleen deficiency,yang deficiency and phlegm turbidity,kidney deficiency,qi deficiency,blood deficiency,marrow reduction,heat toxin syndrome number in dementia type was not statistically significant(P>0.05).(2)Considering compound syndromes,Marrow depletion syndrome and Phlegm turbid syndrome,Marrow depletion syndrome and Yang deficiency syndrome,Marrow depletion syndrome and Spleen deficiency syndrome,Marrow depletion syndrome and Kidney deficiency syndrome,Marrow depletion syndrome;Phlegm turbid syndrome and Spleen deficiency syndrome,Marrow depletion syndrome Spleen deficiency syndrome and Yang deficiency syndrome,Marrow depletion syndrome;Phlegm turbid syndrome and Yang deficiency syndrome,which is more common(frequency ratio>30%)in AD group.Marrow depletion syndrome and Yin deficiency syndrome,Marrow depletion syndrome and blood stasis syndrome,Yin deficiency syndrome and blood stasis syndrome,Marrow depletion syndrome and Kidney deficiency syndrome,Yin deficiency syndrome and Kidney deficiency syndrome,Marrow depletion syndrome;blood stasis syndrome and Yin deficiency syndrome,Yin deficiency syndrome;Kidney deficiency syndrome and Marrow depletion syndrome,Marrow depletion syndrome and Phlegm turbid syndrome,Marrow depletion syndrome;Kidney deficiency syndrome and blood stasis syndrome,Marrow depletion syndrome;Kidney deficiency syndrome;blood stasis syndrome and Yin deficiency syndrome,Marrow depletion syndrome and Spleen deficiency syndrome which is more common(frequency ratio>30%)in VD group.(3)Some compound syndromes types are selected for comparison.The frequency incidence of Marrow depletion syndrome and Yin deficiency syndrome,kidney deficiency syndrome and Yin deficiency syndrome,blood stasis syndrome and Yin deficiency syndrome in VD group was higher than that in AD group(P<0.05).The frequency incidence of Marrow depletion syndrome and Phlegm turbid syndrome,Marrow depletion syndrome and Yang deficiency syndrome,blood stasis syndrome and yang deficiency syndrome in AD group was higher than that in VD group(P<0.05).Conclusion:1.In this research traditional Chinese medicine syndromes of AD and VD were common in myelopenia syndrome and kidney deficiency syndrome.The number of Yang deficiency syndrome and phlegm turbidity syndrome in AD group was more than VD group.The number of Yin deficiency syndrome,blood stasis syndrome in VD group was more than AD group.2.Bad living habits and vascular injury factors are closely related to the incidence of dementia.VD patients should pay more attention to the intervention of adverse lifestyle、vascular injury factors and disease.