Clinical Observation Of Xinshuai Ⅳ Prescription In The Treatment Of Chronic Heart Failure With Coronary Heart Disease (deficiency Of Yin And Yang, Stop Of Blood Stasis And Water)

Objective:Objective To observe the clinical effect of Xinshuai No.Ⅳ prescription in the treatment of coronary heart disease(CHD)with chronic heart failure(CHF)due to deficiency of yin and Yang and stagnation of blood stasis and water,and to evaluate its safety,so as to provide basis for its clinical use.Methods:To observe the patients who met the inclusion criteria and voluntarily participated in the clinical trial from October 2019 to June 2020 in the Department of Cardiology of Changsha hospital of traditional Chinese medicine.They were divided into control group and treatment group according to the principle of random control.The control group was treated with standardized western medicine,and the treatment group was treated with standardized western medicine combined with No.Ⅳprescription for heart failure.The course of treatment was 2 weeks.After the end of the trial,the TCM syndrome score,NT-proBNP,LVEF,cardiac function classification,6-minute walk test and Minnesota quality of life score of the two groups before and after the treatment were recorded.The TCM syndrome efficacy and cardiac function efficacy were calculated and statistically analyzed.The safety indexes during the trial were monitored to complete the clinical efficacy comparison and safety analysis.Results:After treatment,the results showed that the TCM syndrome efficacy,TCM syndrome score,cardiac function efficacy,NT-proBNP,LVEF value,Minnesota quality of life score of the two groups were improved compared with those before treatment,and the effect of the treatment group was significantly better than that of the control group,the difference was statistically significant(P<0.05).In the aspect of experimental safety,there was no obvious abnormality in the safety indexes such as hematuria,fecal routine,liver and kidney function,electrolyte,myocardial enzyme and coagulation routine before and after the experiment.There were a few adverse reactions in the control group,which recovered without any treatment,and no adverse reactions in the treatment group.Conclusion:The treatment group was superior to the control group in TCM syndrome score,TCM syndrome efficacy,cardiac function efficacy,NT-proBNP level,LVEF value and Minnesota quality score scale.There was no adverse reaction in the whole process of the experiment,and the safety of the experiment was good.