Study On The Polysaccharide Peptide Extract Of Panax Quinquefolius Stem Leaf And The Blood Glucose,Blood Lipids-lowering Function Of Panax Quinquefolius Polysaccharide Peptide On Diabetic Mice

To study Panax quinquefolius polysaccharide peptide on diabetes mellitus mice fall blood glucose,blood lipid and antioxidant effect.Paper use the research methods such as biochemistry,molecular biology,focus from Panax quinquefolius polysaccharide peptide promote insulin secretion,repair islet cell function,improve the insulin resistance,and regulate the body’s sugar,lipid metabolism and antioxidant capacity,etc,this paper discusses the function mechanism of Panax quinquefolius polysaccharide peptide fall blood glucose and blood fat,for Panax quinquefolius polysaccharide peptide scientific use of provide a reference basis.The main results were as follows:(1)Panax quinquefolius polysaccharide peptide in 1:10 of material liquid,microwave time is 2.5 min,extraction times three conditions,the extraction effect is good,high extraction efficiency.The polysaccharide peptide extraction yield is 12.457%,the content is 73%.(2)Female ICR mice fasting before 16 h,220 mg/kg intraperitoneal injection of alloxan solution,can be successfully established diabetic mouse model,its modulus rate is high,the mortality rate is low,and stable,suitable for the experimental study of diabetes.(3)Panax quinquefolius polysaccharide peptide can significantly improve the general physical condition of experimental diabetic mice,the concentration of fasting glucose,and other typical symptoms of diabetes,that Panax quinquefolius polysaccharide peptide has a significant effect to reduce blood glucose.Inhibits glucose caused by elevated blood glucose,reduce animal postprandial blood glucose,significantly of glucose tolerance to reduce in mice,Panax quinquefolius polysaccharide peptide was verified with regulating glucose metabolism and prevention of metabolic syndrome,islet cells,etc.(4)Panax quinquefolius polysaccharide peptide on experimental diabetic mice serum TC,TG,LDL-C contents to reduce and the content of HDL-C rise has significant effect.Lipid metabolism disorder in diabetes mice and Insulin resistance is improved and islet beta cell function restoration,the increased insulin sensitivity,which have the effect of fall blood glucose.(5)Panax quinquefolius polysaccharide peptide effectively reduce the serum content of MDA in diabetic mice,increase the activity of SOD and GSH-px,thereby promoting the removal of free radicals in the body and enhance the antioxidant ability of mice,eventually achieve the goal of fall blood glucose.