| [Objective]The mesoporous silica nanoparticle was prepared by the template method and the preparation parameters were optimized n the process of experiment.Through the preparation of mesoporous silica nanoparticles on the loading of oridonin,the prepared method,drugs loading,best reaction time and best drug concentration were examed.[Method]The ordered mesoporous silica nanoparticles were mainly prepared by the template method.The sample was analysized by SAXS,BET,SEM and TEM.The oridonin was transferred to the ordered mesoporous silica by the liquid phase transfer method and evaluated the effect in simulated body fluid.The pharmacokinetic parameters of mice was tested by DAS 2.0 pharmacokinetic software.[Results]The SEM and TEM of samples can be clearly seen that mesoporous silica nanoparticles were successfully prepared by the template method.The microstructure of sample is spherical which diameter is about 100 nm,aperture size is about 3 nm.In addition,the SAXS result was consisited with the observation of SEM and TEM.The specific surface area of the mesoporous silica was 828.5 m2/g by BET.Mesoporous silica drug loadings was 33.5%,the oridonin loaded into the mesoporous silica.Oridonin hole silica nanoparticlesdrug release slowly,10 hours later,the release rate of the free oridonin group was 87.58%,and the release rate of the oridonin mesoporous silica nanoparticles was 48.67%,reached for mesoporous silica to drug slow release effect.According to the pharmacokinetic parameters of mice,oridonin hole silicon solution metabolism is different from silicon solution.[Conclusion]The application of the template method can be successful synthesis of ordered mesoporous silica,the method is simple and feasible.Microstructure of mesoporous silica nanoparticles were sphere,uniform size,shape stability which had higher drug loadings.The release speed of oridonin hole silica nanoparticles drug was slow.Notably,there is no sudden release effect. |
PDF Full Text Request