The Preparation And Study On Drug Release Properties Of Mesoporous Bioactive Glass And Its PH-sensitive Nanocomposite Hydrogels

Dendal pulp is the only soft tissue which serves to provide nutrition for the teeth and to form dentin.The pulp is located in the pulp cavity and the root canal.Root canal cure is the first-rate option for the therapy of pulpal and periapical diseases,characteristices of root filling material influence the results of root canal treatment.At present,the most commonly used root canal filling materials are gutta-percha,calcium hydroxide and zinc-oxide eugenol paste.While,root canal filling materials which are used in both study and clinical are rarely discussed.Therefore,to develop new root canal filling materials which can compensate for the deficiency of the existing materials and induce odontogenic differentiation and dentin formation received extensive attention these days.Bioactive substances such as growth factors,can promote dental pulp-dentin repairing,but the bioactive macromolecules can’t exist in vivo for a long time.In this paper,we focus on the application of bioactive glass nanocomposite hydrogel with anti-inflammatory properties and the ability which can be used in the field of root canal filling material for dental pulp repair.In this study,MBGs were effectively fabricated by template self-assembly technology combining alkali-catalyzed sol-gel method.The preparation conditions were measured by adapting the amount of HDA,the ratio of alcohol to water and the concentrations of ammonia.With the decreaseing of MBGs size,the apatite-forming ability and ion release rate increased.When the concentrations of HDA,the ratio of alcohol to water and the concentrations of ammonia were 0.04 M,3 and 0.2 M,respectively,MBGs had spherical morphology,good dispersibility,narrow particle size distribution and multi-level structure.Ground on the chapter two,we obtained the MBG-Se by using SeO3 instead of SiO2.The educts exhibited that incapacitating sufficient Se,the micro-nano-bioactive glass still exhibited good dispersibility and regularly spherical morphology,and the particle size,chemical constitution and crystal structure were not changed obviously.The present work explains the preparation of new pH-sensitive bionanocomposite beads based on carboxymethyl cellulose(CMC)and MBGs nanoparticles by in situ polymerization for use as controlled release drug delivery systems.Acetylsalicylic acid(ASA)has been chosen as a model drug.Characterization of the pH-sensitive bionanocomposite beads resulting from incorporation of different content of MBGs nanoparticles into CMC matric was carried out using different experimental techniques:FT-IR,XRD,TGA and SEM.ASA incorporation efficiency in beads was determined by UV-vis spectroscopy and was found to be high.In vitro drug release test was carried out to prove the effectiveness of this novel type of bionanocomposite hydrogel beads as a controlled drug delivery system.