Fabrication Of Non-enzymatic Glucose Electrochemical Sensors Based On Copper-based Nanocatalysts

Glucose is widespread in nature and has important application value in the food industry and medical field.Therefore,the detection of glucose has always been a research hotspot.Copper and its complex have been widely used in glucose detection in recent years due to their excellent conductivity and catalytic ability to glucose.Nickel or copper foams,with their unique three-dimensional porous structures,large specific surface areas and abundant catalyst loading sites,are often used as an conductive substrate.By combining the advantages of metal foams and copper-based catalysts,this work introduces two integrated electrodes of foam metal-supported copper-copper oxide composite nanoarray and copper selenide microsphere film.Both of these two electrodes exhibit rapid and ultrasensitive recognization toward glucose.The research contents and conclusions of this paper are as follows:1.A copper-copper oxide/nickel foam composite nanoarrayed electrode was constructed by one-step hydrothermal-deposition method and further applied to rapid electrochemical detection of glucose.Due to the good electrocatalytic activity of this material,the constructed electrochemical sensing platform based on this electrode show good sensing performance toward glucose with large linear detection range of 0.25-337μM and 337-1187μM,low determination limit of 0.25μM,high sensitivity of 19600μA m M^-1cm^-2and fast response time of 3 s.Besides,this electrode also shows good feasibility in glucose detection in diluted human serum（10%）and orange juice samples with high recovery.2.A monolithic copper selenide microparticle film/copper foam electrode was constructed by hydrothermal selenization of commercial copper foam and further used for sensitive electrochemical detection of glucose.The material shows excellent electrocatalytic oxidation activity toward glucose with ultrahigh sensitivity of 18660μA m M^-1cm^-2,low determination limit of 0.25μM,fast response time of 3 s,and good recovery in real samples of human blood serum and orange juice.