Preparation And Drug Release Properties Of Bio-based Drug-loaded Fibers By Microfluidics Spinning

With the improvement of people’s living standards,the application of textile fibers is no longer limited to warmth and cold protection,but also in the field of industrial environmental protection,construction,and biomedicine.Fibrous materials have attracted much attention in the field of biomedicine due to their large specific surface area,good flexibility and good post-processing,and are often used as drug carriers or tissue scaffolds.Microfluidic spinning technology uses the hydrodynamic effect in microchannels to prepare fibers,and the green preparation of microfibers can be completed at normal temperature and pressure.This paper aims to develop a kind of bio-based drug-loaded microfibers.Two kinds of drug-loaded composite fibers were prepared by microfluidic spinning technology and ionic crosslinking curing principle,and the drug release properties and drug release mechanism of the drug-loaded fibers were analyzed.Firstly,3 wt%chitosan(CS)solution and 15 wt%pullulan(Pul)solution were mixed according to different mass ratios to obtain the spinning solution as the core solution,and different concentrations of sodium tripolyphosphate(TPP)solution as the sheath layer to prepare CP composite fibers by coaxial microfluidic spinning.The results showed that when the mass ratio of CS solution to Pul solution was 1:1,2:1 or 3:1,the concentration of TPP solution was 2 wt%,6 wt%or 10 wt%,the rotation rate of drum receiving device was 25 r/min,the translation rate was 1 mm/min,the flow rate of core solution was 8 mL/h,and the flow rate of sheath solution was 25 mL/h,CP fiber could be successfully prepared,and the fiber was well formed.The uniform arrangement of fiber membrane could also be formed by the same process.Chitosan was successfully cross-linked with sodium tripolyphosphate,and only physically blended with pullulan polysaccharide.CP composite fiber has better swelling property and can be used in the field of drug release.Secondly,based on the preparation process of CP composite fibers,CS/Pul/AAP(CPA)composite fibers were prepared by adding different mass fractions of pacetamidophenol(AAP)as the core layer spinning solution in CS/Pul spinning solution.The drug-sustained release effect of drug-loaded fibers was tested.Studies have shown that the CPA fibers are well formed and the drug does not crystallize.The cumulative drug release rate of CPA composite fiber can reach 59.16%within 150 minutes,which has the effect of drug sustained release.And the drug release kinetic model of CPA composite fiber drug release curve is in good agreement with Korsemeyer-Peppas model and Higuchi model.According to the drug release characteristics of the composite fiber,it is suitable for the treatment of some acute diseases,which not only avoids the damage caused by the release of a large number of drugs in a very short time,but also avoids the failure to release enough drugs in a long time to achieve the purpose of timely inhibition.Finally,hydrophobic chitosan was replaced by hydrophilic sodium alginate as the skeleton material.Blend it with pullulan polysaccharide and AAP as core spinning solution.SA/Pul/AAP(SPA)composite fibers were successfully prepared by microflow spinning.The process parameters of preparing SPA composite fiber are as follows:SA concentration of 3 wt%and Pul concentration of 15 wt%are blended according to different mass ratios to prepare mixed solution,and then different mass fractions of AAP are added as core spinning solution.0.1 mol/L CaCl2 solution was used as sheath solution.Microfluidic spinning process parameters are as follows:rotating speed of receiving device is 50 r/min,translation speed is 4 mm/min,core solution flow rate is 10 mL/h,sheath solution flow rate is 30 mL/h.The results showed that SPA fiber was well formed.SA,Pul and AAP were physically blended and the drug did not crystallize.The drug release time of SPA fiber can reach 50 h,and the cumulative release percentage of AAP can reach 69.19%,which has a good drug sustained release effect.The release curves of SPA composite fibers prepared with SA/Pul of 2:1,3:1 and 4:1 were more consistent with the Weibull model.According to the drug release characteristics of the composite fiber,it can be applied to some drugs for the treatment of chronic diseases,reduce the number of medications,and achieve long-term effective drug release.