Study On Synthesis Of α-Amino Ketone Catalyzed By Visible Light Redox

Visible light is a natural resource that is easy to obtain,inexhaustible,and safe and clean.Visible light catalytic reaction is an efficient green synthesis process that can continuously convert clean light energy directly into chemical energy.Generally,coordination compounds of metals such as ruthenium and iridium or organic photoelectric material molecules such as 4CzIPN are used as photocatalysts.Under the excitation of visible light,high-level electrons undergo transitions,and the excited photocatalysts and substrates undergo single electron transfer or energy transfer,And then generate various high-activity reaction intermediates represented by free radicals,so as to realize the reaction process of building various carbon-carbon bonds or carbon-heterobonds.Compared with traditional organic photochemical reactions,visible light catalytic reactions have unique catalytic properties.Therefore,in the past few years,such visible light redox catalytic reactions have attracted a lot of attention from the academic community,and a series of major research progress has been made.Carboxylic acid is a cheap and easily available chemical synthesis raw material.However,limited by the stable reactivity of carboxylic acid,a large number of synthesis processes require pre-activation of carboxylic acid to achieve subsequent conversion,and the direct conversion of carboxylic acid is relatively scarce,mainly based on the formation of alkyl radicals.Reaction,the reaction path not only often has harsh conditions,but also puts forward certain requirements on the applicability of the substrate.α-Aminoketone is an important organic small molecular structure,which is widely present in various natural products and drug molecules,and has unique biochemical activities.At the same time,the structure of α-amino ketone has multiple active sites,which can realize a variety of different functional groups,and is an important synthetic intermediate in synthetic chemistry.In this paper,with the help of visible light redox catalysis,the synthesis of α-aminoketone from acyl radicals initiated by carboxylic acid decarboxylation has been deeply studied.A synthetic strategy for visible light redox-catalyzed deoxygenation of carboxylic acid to generate acyl radicals has been developed,which promotes the one-step reaction of non-activated carboxylic acid and imine to form α-aminoketone.Under mild reaction conditions,the iridium complex excited by visible light captures the electrons of triphenylphosphine,thereby promoting the deoxygenation of non-activated carboxylic acid to generate acyl radicals,and further attacking the imine substrate,which is the preparation of α-amino ketone Provides a simple and efficient solution.