The Addition Reaction Of 4-Acyl-1,4-Dihydropyridines With Imines

Aminoketones are important nitrogen-containing compounds,which have received extensive attention as antidepressants and anesthetics.Aminoketones can also participate in the reaction as analogs of choline and neurine due to their similar structure to amino alcohols.In addition,aminoketone compounds can also be used as key synthetic intermediates for nitrogen-containing heterocyclic compounds such as pyrrole and pyrimidine.At the same time,it can also be used as a photoinitiator to participate in the photopolymerization reaction.As an important nitrogen-containing heterocyclic compound,1,4-dihydropyridines can be used as drugs to participate in the treatment of hypertension,cardiovascular and cerebrovascular diseases,and have high physiological activity.In recent years,it has attracted much attention for its participation in redox reactions as hydrogen donor and the participation of donors such as alkyl,acyl,and carbamoyl groups in substitution reactions and addition reactions.4-Acyl-1,4-dihydropyridine compounds can release acyl radicals under blue light irradiation,and the supply of acyl groups can be realized without photocatalysts,making 4-acyl-1,4-dihydropyridines a remarkable free radical reagent.In this paper,the radical acylation addition of imine compounds with this reagent was studied.Using DCM as solvent,25 different aminoketones were achieved without any additional additives.The scope of the reaction was explored: substituent groups in different positions,steric hindrance of substituent groups,electronic properties of substituent groups.The reaction is carried out at room temperature without any additives through a free radical mechanism,which broadens the preparation methods of amino ketones.