Construction Of Metal Nanomaterial-carbon Nanotube Flexible Composite Membrane And Its Application In Electrochemical Detection Of Azithromycin

Azithromycin is a second-generation macrolide antibiotic widely used in the treatment of bacterial-induced pharyngitis,pneumonia,urethritis and cervicitis,as well as skin and soft tissue infections,and others’ infections.Due to human abuse,the concentration of azithromycin in the environment has risen sharply,which will bring huge potential threats to the ecological environment and human life and health.Therefore,the sensitive and rapid determination of azithromycin in the environment is of great significance to control its pollution in the environment.In this paper,the carbon nanotube membrane is used as the flexible substrate electrode,and the metal nanomaterial is modified to construct a flexible electrochemical sensor of metal nanomaterial-carbon nanotube,and its application in the detection of azithromycin in the water environment is studied.The main research work and related results are as follows:(1)Multi-walled carbon nanotube films(MWCNTs)were prepared by vacuum filtration,and then gold-palladium alloy nanomaterials(AuPd)were synthesized by electrochemical deposition,and AuPd-MWCNTs composite membrane was prepared,then the morphology of them was characterized by Scanning electron microscope(SEM)The electrochemical properties of AuPd-MWCNTs flexible membrane were investigated by cyclic voltammetry(CV)and differential pulse voltammetry(DPV).At the same time,the effects of the hydrophilicity of the MWCNTs film,the electrodeposition time of AuPd nanoparticles,the enrichment potential and time,the p H of the solution,and the tortuosity on the electrochemical response of azithromycin were investigated.Under the optimal experimental conditions,the AuPd-MWCNTs film via the DPV method,and the determination effect of azithromycin was good,showing a lower detection limit of 0.069 μmol/L and a linear range of 0.6-100 μmol/L.In addition,the AuPd-MWCNTs flexible electrochemical sensor had good selectivity,reproducibility and stability,and the detection of azithromycin in river water samples obtained satisfactory recovery.(2)Copper-palladium nanodendritic material(Cu Pd)supported on MWCNTs membrane(Cu Pd-MWCNTs)by a simple electrochemical deposition method and displacement method,and a flexible electrochemical sensor of Cu Pd-MWCNTs for the determination of azithromycin was constructed.The electrochemical deposition conditions of Cu Pd nanodendrites material were simply explored by SEM,and the electrochemical properties of Cu Pd-MWCNTs composite membrane were characterized by CV and DPV methods.The parameters such as supporting electrolyte concentration,adsorption time,solution p H,and tortuosity were optimized in the experiment.Under the optimized experimental conditions,the Cu Pd-MWCNTs flexible electrochemical sensor had a linear range of 0.25-100 μmol/L for the detection of azithromycin,and the detection limit was 0.014 μmol/L.In addition,the Cu Pd-MWCNTs composite membrane exhibited good selectivity,high satisfactory results were obtained for the determination of azithromycin in actual water samples.