| Silicone hydrogels are ideal biomaterials with good biocompatibility and physiological inertia.However,there are few reports on intelligent response silicone hydrogels.In work,we innovatively designed and synthesized light-responsive bridged silane functional monomer,silane-modified polyethylene glycol,and active silane-capped polyurethane prepolymer for photo-responsive degradation.Based on the sol-gel method,combined with the dynamic reversibility of the crosslinked structure,we innovatively constructed light-responsive silicone/polyvinyl alcohol hydrogel(NB-PVA),light and pH-responsive siliconepolyethylene glycol hydrogel(NB-PEG),light-and pH-responsive degradation siliconepolyurethane hydrogel(NB-PUT)materials.The swelling ability of NB-PVA and NB-PUT was significantly improved after 365 nm illumination,the network structure of NB-PVA and NB-PUT changed significantly,and the pore diameter of NB-PUT xerogel changed from 70 μm to 250 μm;The designed and synthesized NB-PVA,NB-PEG,and NB-PUT silicone hydrogels were degraded in pH=1.2.The micromorphology,swelling behavior,thermal behavior,mechanical strength,and drug release behavior of the designed and synthesized silicone-polyethylene glycol hydrogel can be effectively controlled by adjusting the light-responsive bridging silane component in NB-PEG.NB-PEG and NB-PUT have good mechanical properties,and the maximum compressive strength can reach 0.652 MPa and 2.51 MPa,respectively,and the corresponding strain is 80%and 90%.With the doxorubicin(DOX)as the probe molecule,the silicone-polyethylene glycol hydrogel(DOX@NB-PEG)and silicone-polyurethane hydrogel(DOX@NB-PEG)encapsulated DOX in situ showed an excellent pH-responsive controlled release DOX behavior in the simulated gastric juice(pH=1.2)environment;DOX is continuously released for up to 11 days,with cumulative releases reaching 99.8%and 91.8%,respectively.Under normal physiological conditions(pH=7.4),a small amount of DOX is released.In the continuous light mode,the silicone/polyvinyl alcohol hydrogel(DOX@NB-PVA)continuously releases DOX at an average rate of 4.7%in 12 h;At the same time,DOX@NBPEG and DOX@NB-PEG have typical photo-controlled DOX release behavior in the"ON/OFF" rradiation mode;The pH-responsive degraded silicone hydrogel material significantly prolonged the residence time of the model drug molecule DOX in the simulated gastric juice(pH=1.2)environment,which has a positive significance in the field of drug release;Designed and synthesized novel light-responsive silicone hydrogel materials can release target molecules in a timely,quantitative,and on-demand manner,which has positive significance in the biomedical field. |
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