Boron-Dipyrromethene Photosensitizers In Antimicrobial And Antitumoral Photodynamic Therapy

Bacterial infections and cancer threaten people’s health.Antibiotics are currently considered as the main method for treating bacterial infections,but antibiotics can easily lead to bacterial resistance,creating new difficulties in controlling the spread of pathogens.In addition,the side effects of conventional cancer treatments such as surgery,chemotherapy and radiotherapy afflict patients.Therefore,it is urgent to develop new effective treatment solutions for bacterial infections and tumor.Photodynamic therapy(PDT)is a novel therapeutic strategy.Photosensitizers produce reactive oxygen species(ROS)under laser irradiation to effectively kill pathogenic bacteria and cancer cells.And it does not produce drug resistance,which has become a hot research topic in recent years.In this paper,we focus on boron dipyrromethene(BDP)photosensitizers as the main research object in the treatment of bacterial infections and cancer,and the main work is as follows:1.Fluoroalkylated BDP nanoparticles for photodynamic sterilization and cancer therapyWe prepared fluoroalkylated BDP(named B-F)and its corresponding alkylated BDP(named B-H).B-F and B-H can self-assemble into nanoparticles(NPs)in aqueous solution.Fluoroalkylated can significantly enhance the intracellular delivery efficiency of nanomedicine.In addition,compared with B-H NPs,B-F NPs possesse enhanced capacity of generating ROS and can more effectively kill S.aureus and cancer cells.2.Copper-Boron dipyrromethene nanoagent for antimicrobial photodynamic therapy and wound healingIn order to improve the bioavailability of BDP and solve the problem that BDP is difficult to assemble in aqueous solution,water-soluble BCu NPs were assembled by the coordination reaction between copper ions and carboxyl groups in phenylalanine and BDP.BCu NPs can produce ROS and cause depression of the bacterial surface as well as leakage of the contents under green light irradiation,leading to an effective destruction of bacteria.In addition,the results of in vivo experiments demonstrated that BCu NPs can effectively kill bacteria on the surface of infected wound tissue and accelerate skin wound healing.