Research On Electrochemical Analysis Methods And Related Instrument For Detection Of Synthetic Drug

The research in this thesis was completed under the support of the 2018 Ministry of Public Security’s"Science and Technology to Strengthen Police Program"project"Development of a Portable Synthetic Amphetamine Drug Analyzer Based on an Artificial Molecular Recognition System"（No.2018GABJC38）.The project has now passed the project acceptance organised by the Science and Technology Informatization Bureau of the Ministry of Public Security,and has been well received by the experts present at the meeting,and the core content of the project is from the research results of this thesis.I have completed the following work in this part of this thesis:1.The development of a common analytical method for amphetamine-type synthetic drugs.Using methamphetamine as the target analyte,a molecularly imprinted polymers of the was prepared using the sol-gel method to form an artificial molecular recognition system with the substance;an electrochemical sensor for methamphetamine was prepared using screen printing technology.The sensor showed a response time of less than 8 min for methamphetamine,a detectable concentration of 7 ng m L^-1（S/N=3）,and a linear range of0.5-9.0μg m L^-1;1000-fold concentrations of theophylline,caffeine,ephedrine hydrochloride,ephedrine salicylate,cocaine,morphine,and other substances did not interfere with the detection results.2.Based on the established general analytical method,an amphetamine-type synthetic drug analyser was designed and assembled.A single-function electrochemical test module was developed and its driver written using a development board from Adino（Italy）;a Windows tablet PC was used as the control system,and data analysis and processing software and a foolproof operating interface were written;a suitcase design was used to assemble the above components into a prototype and to complete the commissioning and application of the whole machine.The prototype was assembled in a suitcase design and commissioned and applied.For the detection of methamphetamine,the analyser was able to give direct results within 8 minutes without the need for complicated sample pre-processing,and was evaluated by a team of experts appointed by the Yunnan Provincial Public Security Bureau.In addition to the above research work,I have also participated in and completed most of the research work for the Jilin Provincial Education Department’s 2022 Industrialisation Incubation Project"New Technology and Equipment for New Coronavirus Disinfection Based on Cold Chain Logistics Packaging".The project has passed the appraisal of scientific and technological achievements organised by the Jilin Provincial Department of Science and Technology.And it has been well received by experts.I have completed the design of the shape of the electrode part,a key component of the prototype,and the method of high voltage application;I have investigated the relationship between the working parameters of the prototype and the killing effect,and optimised and determined the optimal working parameters of the prototype.A specific scheme for evaluating the effectiveness of the prototype under different scenarios was developed.