Studies On Yttrium-Catalyzed Stereoselective 2-Deoxyglycosylation

Proteins,nucleic acids,and sugars are three essential organic compounds in the human body.Carbohydrates,as the energy source of the human body,participate in life activities such as immune response,inflammation,viral infection,sperm and egg recognition,and blood type determination,and play an important role.Due to the complex and diverse structure of carbohydrates,the synthesis of carbohydrate compounds faces challenges.This paper studies the 2-deoxyglycosides replaced by hydrogen atoms.Due to the protection of the two unprotected radicals,the stereoselective regulation ability in the construction of 2-deoxyneneneba glycosidic bond is reduced,and its glycosidic bond is relatively unstable and sensitive to water and acid,which makes the construction of 2-deoxynenenebc glycosidic bond a difficult point in sugar chemistry research.In view of the potential pharmaceutical value of sugar compounds and the increased drug activity after glycosylation,The main way to get simple and clear carbohydrate compounds is chemical synthesis,whose core is the construction of glycosidic bond.In this paper,a method for the construction of 2-deoxy glycosidic bond catalyzed by yttrium metal was developed α Stereoselective generation of 2 deoxyglucoside products with high yield.Has excellent substrate tolerance,suitable for different functional groups,substrate receptors,and glycosyl donors.This method is simple and convenient,and it does not need to add molecular sieves as the reaction process of constructing glycosidic bond.