Preparation Of Graphdiyne And MOF Based Nanomaterials And Their Antibacterial Properties

Traditional antibacterial materials（antibiotics,antimicrobial peptides,metal-based antimicrobials,cationic polymers）are hampered by their inherent defects（such as antibiotic resistance,the inherent toxicity of metals）in the field of antibacterial further application.In order to solve these problems,in recent years,new carbon materials and MOF materials have been widely used in the field of antibacterial,and show excellent antibacterial properties.In this paper,the preparation and antibacterial properties of graphite-alkyne and MOF-based nanomaterials were studied,and their antibacterial mechanism was described in detail.1.The use of acetylene coupling method to synthesize graphdiyne,oxidized to get graphdiyne oxide nanosheet,using the plate counting method to explore its and Staphylococcus aureus,Escherichia coli,pseudomonas aeruginosa,Bacillus subtilis after the bacterial colony changes,bactericidal rate can reach 99.999%and 99.9%,respectively.The mechanism is caused by the nanoknife effect generated by the sharp edges of graphdiyne and the mediated generation of reactive oxygen species（ROS）,in which the physical action can enhance the antibacterial factor by changing the conditions,i.e.treatment time,concentration and oscillation speed.2.ZIF-8 nanocomposites loaded with molybdenum disulfide quantum dots（Mo S₂QDs）were synthesized by solution method.The porous structure of ZIF-8 provides a place for Mo S₂ QDs to load,effectively avoiding the aggregation of quantum dots.The antibacterial activity of Mo S₂ QDs@ZIF-8 was obtained by the plate counting method.The bactericidal activity of Mo S₂ QDs@ZIF-8 against Staphylococcus aureus and Escherichia coli reached 92.8%and 81.2%respectively after 2 h.Under the condition of xenon lamp irradiation,the antibacterial activity was further enhanced to 99.5%and98.4%.The antibacterial mechanism is studied,and it was found that oxidative stress of quantum dots played an important role in the antibacterial effect.Under photon excitation,quantum dots will generate electron-hole pairs with strong reducing and oxidizing ability,which react with dissolved oxygen and water respectively to form ROS destroying biomolecules,and further improve their antibacterial performance.3.Cu@ZIF-8 was synthesized by a simple solution method.It was found that it had good photothermal conversion performance under near infrared light irradiation,and the release of Cu²⁺would destroy the internal DNA and protein and lead to bacterial inactivation.Under near-infrared light irradiation,its antibacterial performance was further improved to 99.5%.Meanwhile,the acidic environment at the infected site would lead to the degradation of the ZIF-8 imidazole skeleton and release the internal Zn²⁺,which further enhanced the antibacterial effect of Cu@ZIF-8 at the infected site.