The Clinical Observation Of "Liujunzi Decoction And Yupingfeng Powder" To Treat The Lung-Spleen-Qi Deficiency Syndrome Of Chronic Obstructive Pulmonary Disease Stabilization Period

Objective To observe the clinical efficacy of Liujunzi Decoction and Yupingfeng Powder in the treatment of patients with stable chronic obstructive pulmonary disease.To explore its efficacy and safety,evaluate the value and advantages of traditional Chinese medicine in the treatment of stable COPD patients.Methods A total of 100 patients who met the inclusion criteria for diagnosis of COPD,including B,C,D,and TCM syndromes,were randomly divided into control group(50 cases)and experimental group(50 cases).Among them,the control group off 4 cases,the experimental group off 7 cases.The control group was treated with western medicine according to the comprehensive evaluation and recommended treatment plan of GOLD guideline.The experimental group was treated with Liujunzi Decoction and Yupingfeng Powder on the basis of western medicine treatment.The TCM treatment period was 6 months,and the observation period was 6 months after treatment.Both groups have established COPD management files,and analyzed the data after the end of this study.Results 1.Clinical efficacy:the total effective rate of the control group is 82.6%,while the total effective rate od experimental group is 93.0%,and the clinical efficacy of the trial group was significantly better than the control group,the difference was statistically significant(P<0.05).2.Quantitative score of TCM symptoms:the quantitative score of the main clinical symptoms in the experimental group and the control group were lower than before treatment(P<0.05),and the quantification score of the symptoms in the experimental group was lower than that of the control group significantly,and the difference was statistically significant(P<0.01).3.Pulmonary function:There were no significant differences in pulmonary function between the two groups before and after treatment(P>0.05).Before and after treatment,there was no significant difference in FEV1,FEV1/expected value,FVC,FEV1/FVC and PEF between the two groups and within the group(P>0.05).4.Quality of life score:The scores of CAT score,mMRC,BODE and 6WMT in the two groups were better than those before treatment(P<0.01 or P<0.05).The experimental group was more improved in the CAT,mMRC,BODE,6WMT,which was statistically significant(P<0.01 or P<0.05).5.Acute exacerbations:the incidence of acute exacerbations in both groups decreased after 1 year treatment(P<0.01).There was statistically significant difference between the two groups(P<0.05).6.Safety:two groups of stable blood tests after treatment,urine,feces three routine,liver and kidney function,ECG,examination were no significant abnormal changes in the observation period were not serious adverse reactions.Conclusion 1.The combination therapy of "Liujunzi Decoction and Yupingfeng Powder" combined with western medicine can significantly improve the clinical symptoms,especially in the cough,sputum,wheezing,chest tightness and shortness of breath and other clinical symptoms better than the control group.2.The combination therapy of "Liujunzi Decoction and Yupingfeng Powder"combined with western medicine can improve exercise tolerance,quality of life,and is better than that of using pure western medicine treatment.And no obvious improvement of lung function.3.The "Liujunzi Decoction and Yupingfeng Powder" can decrease the times ofacute exacerbation,and no significant abnormal changes were not serious adverse reactions,to provide a basis for further development of clinical application of chronic obstructive pulmonary disease...