Association Of VDBP And Syntax Score In Patients Of Acute ST-segment Elevation Myocardial Infarction

Objective: To investigate the association of the level of serum vitamin D binding protein(VDBP)and the risk of acute ST-segment elevation myocardial infarction(STEMI);To explore the relationship between VDBP and the severity of coronary lesions by Syntax score.Methods: 74 patients with STEMI were enrolled,and 50 healthy volunteers who underwent physical examination at the same time were selected as the control group.The serum VDBP levels were measured by enzyme-linked immunosorbent assay(ELISA),the clinical data were collected,and the Syntax scores were calculated.According to the Syntax score,the experimental group was divided into 3 groups,including high-risk group(Syntax ≥ 33,n = 21),intermediate-risk group(23 ≤ Syntax ≤ 32,n = 25)and low-risk group(Syntax ≤ 22,n = 28),comparing the difference of VDBP between these 3 groups,and analysing the correlation between VDBP and Syntax scores.Results: VDBP level in STEMI patients was significantly higher than that in the control group[(3.43±1.11)μg/mL vs(2.28±1.15)μg/mL,p<0.05].There was no significant difference of VDBP between the STEMI group(F=1.020,P=0.366).There was no significant correlation between VDBP and Syntax score(r=0.143,p=0.223).Conclusion: VDBP level in STEMI patients is significantly higher than that in control groups,which may be an important indicator for clinical diagnosis of STEMI,but it can not indicate the severity of coronary lesions.