Mapping The Trends In Esophageal Cancer Disease Burden In The United States:Results From The Global Burden Of Disease Study 2017

Background:Esophageal cancer is the 7th leading cancer globally and the 10th leading cancer in the United States.However,it is has received limited attention over more common malignancies.Only a few studies have comprehensively assessed disease burden from esophageal cancer in the United States(US).The purpose of this study is to explore the relationship between the burden of esophageal cancer and gender,economic level and various risk factors through analyze the burden of esophageal cancer in US,so that to provide reference for China’s prevention and control of esophageal cancer.Methods:Using states-categorized data on incidence,mortality,and Disability-adjusted life years(DALYs),this study analyzed their age-standardized rate(ASR)and estimated annual percentage change(EAPC)to estimate the current trends in esophageal cancer disease burden.Data were obtained from Global Burden of Disease(GBD)online resource and used to determine annual relative change.Results:We report here that between 1990 and 2017,the number of esophageal cancer new cases,deaths and DALYs in the US increased significantly,while the ASR of incidence remained constant but ASRs of mortality and DALYs trended to decrease.During the same time,disease burden from esophageal cancer in males was higher than that in females.Economically stronger states trend to had lesser disease burden from esophageal cancer.Smoking and alcohol use contributed most of the burden while influence of high body-mass index and diet low in fruits grew largely.Conclusions:This study provided an analysis of esophageal cancer disease burden in the United States that will inform the design of targeted strategies for disease prevention tailored to different states,which could serve as a reference for China’s prevention and control of esophageal cancer.