| BackgroundObesity,which is characteristic by excessive accumulation or abnormal distribution of fat,is defined as a complex chronic disease that has harmful effects of health.The prevalence of overweight and obesity has increased sharply among undergraduates worldwide,which is one of the most pressing global public health problem now.Identification of metabolically healthy obesity(MHO)and metabolically unhealthy obesity(MUHO)can help predict different kinds of obese phenotypes-related complications and the risk of death.There are three guidelines recommendations of obesity treatment:lifestyle-integrated intervention,drug treatment and surgical treatment,of which dietary intervention is a cornerstone in the prevention and treatment of obesity.At present,there is no research on the influence of calorie-restricted and low-carbohydrate diet intervention on different obese phenotypes at home and abroad.ObjectivesThis study investigated body weight,fat distribution,glycolipid metabolism indexes of different obese phenotypes inder to provide the effects of a 12-week calorie-restricted and low-carbohydrate diet intervention on MUHO and MHO subjects and compare differences between the two groups.The results can provide basis and guidance for the diagnosis and treatment of different obese phenotypes and related complications in the future.MethodsAll cases data were derived from a prospective,multicenter,randomized controlled clinical study with short-term calorie-restricted and low-carbohydrate diet intervention for weight management in overweight/obese patients,led by the Department of Endocrinology and Metabolism of Zhujiang Hospital in Southern Medical University in 2018.There were 52 obese patients in the study.We collected basic medical history of cases that meet the inclusion criteria,then measured blood pressure,height,weight,waist circumference,hip circumference and calculated body mass index as well as waist-hip ratio;recorded fasting blood glucose,fasting insulin,total cholesterol,triglycerides,low-density lipoprotein cholesterol,high-density lipoprotein cholesterol,alanine aminotransferase,aspartate aminotransferase,uric acid,hypersensitivity C-reactive protein and other indicators,then calculated the insulin resistance index.Besides,we collected body fat rate,muscle rate,visceral fat area measured by body composition analyzer and results of liver B-ultrasound in the database.Results1.Compared with the metabolic syndrome standard of Chinese Medical Association Diabetes Branch in 2017,the JIS diagnostic standard in 2009 can identify more obese groups with abnormal metabolismhas when distinguishing obese phenotypes.2.Short-term calorie-restricted and low-carbohydrate diet interventions can reduce MUHO group’s weight,triglycerides(P<0.001)and improve their body shape,body fat distribution,insulin resistance and so on.3.There was no significant difference between MUHO and MHO patients before and after short-term calorie-restricted and low-carbohydrate diet intervention in terms of weight,body shape,body fat distribution,glucose metabolism,liver function,uric acid,and inflammation indicators.However,MUHO group had a more significant effect on reducing triglycerides after 12-week diet intervention(P<0.05).4.There were 70.8%of MUHO group converted to MHO after a short-term calorie-restricted and low-carbohydrate diet intervention.ConclusionsThis study retrospectively analyzed the effects of 12-week calorie-restricted and low-carbohydrate diet intervention on MUHO and MHO people,and confirmed that the diet can effectively reduce weight,improve body fat distribution and glycolipids metabolism indicators of the two obese phenotypes.What’s more,this short-term calorie-restricted and low-carbohydrate diet promoted MUHO convert to MHO.Hocever,follow-up large-scale studies of long-term diet intervention are still needed to verify its effectiveness. |
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