The Analysis Of The Global Signal In Children With Congenital Sensorineural Deafness-A Resting State Functional Magnetic Resonance Study

Objective: To evaluate the functional connective between the global signal(GS)and the local brain area of the congenital sensorineural hearing loss(CSNHL) and the normal healthy group(HC),the global signal correlation(GSCORR)is used.To explore the abnormal activity of the global signal in the CSNHL children group compared with the normal control group,so as to find the abnormal activity coupling and changes of the global signal and the neurons themselves in the CSNHL children.Methods: 48 CSNHL patients and 41 healthy controls underwent resting-state f MRI scans.Calculating the global signal and local brain region signals of the two groups,the global signal correlation(GSCORR)was used to evaluate the difference between the two groups of data.Removing the control variables age and gender,the difference of the global signal coherence between the two groups was evaluated by using the two-sample T test(0.05).Results: Compared with the healthy control,the functional connective between the global signal and brain regions in the CSNHL group was significantly reduced in the thalamus,basal ganglia and left insula,and the difference was statistically significant(T value was-3.94-4.33-3.35,q < 0.05).It shows that the signal in the local area of children with CSNHL have abnormal activities.Conclusion:(1)The global signal of children with congenital sensorineural deafness carry valuable information that can represent neuronal activity;(2)The global signal in children with congenital sensorineural hearing loss were coupled with the local brain regions.