The Dose-Response Meta-Analysis Between A Few Risk Factors And Breast Cancer

Objective To analyze and evaluate the dose-response relationship between some risk factors and the breast cancer in Chinese female population and get the effects of different exposure levels,so as to provide some reference for the establishment of a breast cancer risk assessment model based on China’s national conditions.Methods Published literatures related to risk factors of breast cancer in Chinese women were searched systemically and assessed by NOS items from 2000 to 2020.STATA 16.0 was used for data analysis and for dose-response analyze.Results 17 studies including 27314 Chinese women were including,while 9,9,10 and 9 literatures for risk factor BMI,age at menarche,age at first childbirth and parity,respectively.NOS score was ≥6 points in all included articles;We could find the nonlinear dose-response relationships in the four risk factors and breast cancer,and the relationships were analyzed by random effect model at the same time.Conclusion 1.BMI has a positive correlation with breast cancer in the population of Chinese female.When BMI is in the range of 18 to 22,the risk of breast cancer is relatively stable,while the risk is significantly increased in BMI > 22,sharply increased in BMI>24 even 28.2.The cut-off points of exposure level in Chinese women may be age 12 and 16 in regard to the age of menarche and breast cancer risk,evaluated preliminarilyin the study.3.The breast cancer risk increase significantly at the age of 17 to 25 at first childbirth,but increase relatively gently after 25,Specifically from 31 to 39.4.Compared with nulliparity,the risk of breast cancer decrease obviously in woman who had one full-term pregnancy,and the overall risk decrease with multiparity.